Centro Studi Sclerosi Multipla, Azienda Ospedaliera S. Antonio Abate di Gallarate, Gallarate, Italy.
Neurol Sci. 2010 Nov;31(Suppl 2):S215-8. doi: 10.1007/s10072-010-0437-8.
Cognitive impairment has been recently recognized in patients with pediatric multiple sclerosis in more than 30% of cases. Altered functions with variable frequency are: attention, language (receptive, verbal fluency, naming), visual-spatial and motor functions, spatial memory, executive functions and abstract reasoning. Fatigue and affective disorders are associated, but not correlated with cognitive impairment. The frequency and severity of cognitive impairment increase with time. Cognitive impairment has a negative impact on patient's life limiting social, academic and recreational activities.
认知障碍在超过 30%的儿科多发性硬化症患者中最近被认识到。改变的功能具有不同的频率是：注意力、语言（接受性、言语流畅性、命名）、视觉空间和运动功能、空间记忆、执行功能和抽象推理。疲劳和情感障碍是相关的，但与认知障碍不相关。认知障碍的频率和严重程度随时间增加。认知障碍对患者的生活产生负面影响，限制了社会、学术和娱乐活动。
