Otto Ronald, Roller Regina E, Iglseder Bernhard, Dovjak Peter, Lechleitner Monika, Sommeregger Ulrike, Benvenuti-Falger Ursula, Böhmdorfer Birgit, Gosch Markus
Universitätsklinik für Innere Medizin, Medizinische Universität Graz, Graz, Austria.
Universitätsklinik für Geriatrie, Paracelsus Medizinische Privatuniversität, Salzburg, Austria.
Wien Med Wochenschr. 2010 Jun;160(11-12):276-280. doi: 10.1007/s10354-010-0786-1.
Diuretics are well studied and evaluated for their beneficial use in geriatric patients. However those drugs are often used without taking care of subjects condition or functional impairment. Known side effects of those substances may be increased by combinations of multiple drugs. Polypharmacy is a strong risk factor for the incidence of adverse drug reactions (ADR). ADRs are frequently found in combination with the use of diuretics. The remodelling of human body in aging process and uncontrolled therapeutic strategies seem to be causal for that finding. This article tries to work out the potential risk of the usage of those drugs in geriatric patients and its clinical relevance by using literature published in PubMed.
利尿剂在老年患者中的有益用途已得到充分研究和评估。然而,这些药物的使用往往没有考虑到患者的病情或功能损害。多种药物联合使用可能会增加这些物质已知的副作用。多重用药是药物不良反应(ADR)发生的一个重要危险因素。ADR经常与利尿剂的使用同时出现。衰老过程中人体的重塑和不受控制的治疗策略似乎是导致这一现象的原因。本文试图通过使用发表在PubMed上的文献,梳理出这些药物在老年患者中使用的潜在风险及其临床相关性。