Braz Henrique Bartolomeu, Barreto Rodrigo da Silva Nunes, Silva-Júnior Leandro Norberto da, Horvath-Pereira Bianca de Oliveira, Silva Thamires Santos da, Silva Mônica Duarte da, Acuña Francisco, Miglino Maria Angelica
Ecology and Evolution Laboratory, Butantan Institute, São Paulo 05503-900, SP, Brazil.
Department of Animal Morphology and Physiology, Faculty of Agricultural and Veterinary Sciences, São Paulo State University, Jaboticabal 14884-900, SP, Brazil.
Animals (Basel). 2024 Jul 16;14(14):2077. doi: 10.3390/ani14142077.
The implantation of the embryo into the maternal endometrium is a complex process associated with the evolution of viviparity and placentation in mammals. In this review, we provide an overview of maternal recognition of pregnancy signals and implantation modes in eutherians, focusing on their diverse mechanisms and evolutionary patterns. Different pregnancy recognition signals and implantation modes have evolved in eutherian mammals, reflecting the remarkable diversity of specializations in mammals following the evolution of viviparity. Superficial implantation is the ancestral implantation mode in Eutheria and its major clades. The other modes, secondary, partially, and primary interstitial implantation have each independently evolved multiple times in the evolutionary history of eutherians. Although significant progress has been made in understanding pregnancy recognition signals and implantation modes, there is still much to uncover. Rodents and chiropterans (especially Phyllostomidae) offer valuable opportunities for studying the transitions among implantation modes, but data is still scarce for these diverse orders. Further research should focus on unstudied taxa so we can establish robust patterns of evolutionary changes in pregnancy recognition signaling and implantation modes.
胚胎植入母体子宫内膜是一个与哺乳动物胎生和胎盘形成进化相关的复杂过程。在这篇综述中，我们概述了真兽类动物母体对妊娠信号的识别及植入模式，重点关注其多样的机制和进化模式。真兽类哺乳动物进化出了不同的妊娠识别信号和植入模式，这反映出胎生进化后哺乳动物在特化方面的显著多样性。表面植入是真兽亚纲及其主要分支的原始植入模式。其他模式，即继发性、部分性和原发性间质植入，在真兽类动物的进化历史中各自独立进化了多次。尽管在理解妊娠识别信号和植入模式方面已取得重大进展，但仍有许多有待揭示。啮齿动物和翼手目动物（特别是叶口蝠科）为研究植入模式之间的转变提供了宝贵机会，但针对这些不同目动物的数据仍然稀缺。未来的研究应聚焦于尚未研究的类群，以便我们能够建立妊娠识别信号和植入模式进化变化的可靠模式。
