高剂量蔓越莓汁对患者华法林药效学的影响。
Effect of high-dose cranberry juice on the pharmacodynamics of warfarin in patients.
机构信息
Northern Arizona VA Health Care System, Prescott, AZ 86313, USA.
出版信息
Br J Clin Pharmacol. 2010 Jul;70(1):139-42. doi: 10.1111/j.1365-2125.2010.03674.x.
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
Case reports suggest an association between cranberry juice and potentiation of warfarin. Studies using 240 ml of cranberry juice daily demonstrated no interaction. It is unknown if higher amounts of cranberry juice will interact with warfarin.
WHAT THIS STUDY ADDS
Cranberry juice at 240 ml twice daily does not alter the pharmacodynamics of warfarin.
AIM
To determine if high-dose cranberry juice (240 ml twice daily) alters the pharmacodynamic action of warfarin.
METHODS
Ten male patients taking stable doses of warfarin were given cranberry juice at 240 ml twice daily for 7 days. Prothrombin times were drawn at baseline and days 2, 6 and 8 after administration of the juice. Prothrombin times were averaged for each day and mean times were compared from each study day to baseline using repeated measures ANOVA.
RESULTS
There was no statistical difference between mean prothrombin time at baseline and any day tested during juice administration.
CONCLUSIONS
Cranberry juice (240 ml twice daily for 1 week) did not alter the pharmacodynamics of warfarin in patients.
已知关于这个课题的情况
病例报告表明蔓越莓汁与华法林的增效作用有关。每日使用 240 毫升蔓越莓汁的研究表明没有相互作用。目前尚不清楚是否大量饮用蔓越莓汁会与华法林发生相互作用。
本研究的新增内容
每日两次 240 毫升的蔓越莓汁不会改变华法林的药效动力学。
目的
确定高剂量蔓越莓汁（每日两次 240 毫升）是否会改变华法林的药效作用。
方法
10 名男性患者在稳定剂量服用华法林的情况下，每天饮用 240 毫升蔓越莓汁两次，共 7 天。在服用果汁前、第 2、6 和 8 天抽取凝血酶原时间。对每天的凝血酶原时间进行平均，并用重复测量方差分析比较从每个研究日到基线的平均时间。
结果
在服用果汁期间，没有一天的平均凝血酶原时间与基线有统计学差异。
结论
在患者中，蔓越莓汁（每日两次 240 毫升，持续 1 周）并未改变华法林的药效动力学。
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