Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA.
Br J Nutr. 2010 Dec;104(11):1696-702. doi: 10.1017/S0007114510002588. Epub 2010 Jul 20.
Although there is evidence that vitamin D deficiency may play a role in depression, studies done on the associations have yielded mixed results. The present study aimed to examine the associations between serum concentrations of 25-hydroxyvitamin D (25(OH)D) and parathyroid hormone (PTH) and the presence of depression among US adults. A cross-sectional, population-based sample (including 3916 participants aged ≥ 20 years) from the 2005-6 National Health and Nutrition Examination Survey was used. Participants' depressive symptoms were assessed using the Patient Health Questionnaire-9 diagnostic algorithm. The associations of 25(OH)D and PTH with depression were explored using multivariate logistic regression models. For all the participants, the age-adjusted prevalence was 5.3 (95 % CI 4.3, 6.5) % for having moderate-to-severe depression, 2.3 (95 % CI 1.7, 3.1) % for having major depression and 3.8 (95 % CI 3.0, 4.6) % for having minor depression. Although the age-adjusted prevalence and the unadjusted OR of having moderate-to-severe depression or major depression decreased linearly with increasing quartiles of 25(OH)D (P < 0.05 for trends), no significant associations remained after adjusting for multiple potential confounders such as demographic variables, lifestyle factors and coexistence of a number of chronic conditions. Neither the age-adjusted prevalence nor the OR (unadjusted or adjusted) of having depression differed significantly by the quartiles of PTH. Thus, in contrast to some of the previous findings, the present results did not show significant associations between serum concentrations of 25(OH)D and PTH and the presence of moderate-to-severe depression, major depression or minor depression among US adults. However, these findings need to be further confirmed in future studies.
虽然有证据表明维生素 D 缺乏可能在抑郁症中起作用，但关于其相关性的研究结果不一。本研究旨在探讨美国成年人血清 25-羟维生素 D（25(OH)D）和甲状旁腺激素（PTH）浓度与抑郁症之间的关系。该研究使用了 2005-2006 年全国健康和营养调查的横断面、基于人群的样本（包括 3916 名年龄≥20 岁的参与者）。采用患者健康问卷-9 诊断算法评估参与者的抑郁症状。采用多变量逻辑回归模型探讨 25(OH)D 和 PTH 与抑郁的关系。对于所有参与者，调整年龄后的中度至重度抑郁患病率为 5.3%（95%CI：4.3%，6.5%），重度抑郁患病率为 2.3%（95%CI：1.7%，3.1%），轻度抑郁患病率为 3.8%（95%CI：3.0%，4.6%）。尽管调整年龄后的患病率和未经调整的中度至重度抑郁或重度抑郁的 OR 随 25(OH)D 四分位的增加呈线性下降（趋势 P<0.05），但在调整了多个潜在混杂因素（如人口统计学变量、生活方式因素和多种慢性疾病共存）后，相关性不再显著。PTH 四分位与抑郁的调整年龄后患病率或 OR（未经调整或调整）均无显著差异。因此，与一些先前的研究结果相反，本研究结果并未显示美国成年人血清 25(OH)D 和 PTH 浓度与中度至重度抑郁、重度抑郁或轻度抑郁之间存在显著相关性。然而，这些发现需要在未来的研究中进一步证实。
