Department of Public Health, Yonsei University Graduate School, Seoul 120-752, Republic of Korea; Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
Cardiovascular and Metabolic Disease Etiology Research Center, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea; Department of Preventive Medicine, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea.
J Affect Disord. 2016 Jan 1;189:357-64. doi: 10.1016/j.jad.2015.09.043. Epub 2015 Oct 9.
This study aims to examine associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and depressive symptoms in an older Korean population.
The study used data from the Korean Urban Rural Elderly study, which enrolled 2942 participants aged 65 years or older from urban and rural communities. After excluding those treated with antidepressants, we conducted cross-sectional analysis of 2853 participants (962 men and 1891 women). Serum 25(OH)D was analyzed as both a continuous and categorized variable. Depressive symptoms were assessed using the Korean version of the Geriatric Depression Scale - Short Form. Multivariate logistic regression analyses were conducted to examine relationships between serum 25(OH)D and depressive symptoms for men and women separately.
In men, ORs (95% CIs) for depressive symptoms were 1.74 (0.85, 3.58), 2.50 (1.20, 5.18), and 2.81 (1.15, 6.83) for those with a 25(OH)D concentration of 20.0-29.9, 10.0-19.9, and <10.0ng/mL, respectively (P-trend=0.013), compared with those with a 25(OH)D concentration of ≥30.0ng/mL, after adjustment for study year, month of assay, age, parathyroid hormone, body mass index, number of comorbidities, smoking status, alcohol intake, exercise, sleep duration, income, education, cohabitation status, and residential area. In women, the associations between 25(OH)D and depressive symptoms were significant neither before nor after adjustment.
Due to the cross-sectional study design, causal association is uncertain. Intake of vitamin D supplements and outdoor activity were not examined.
Our findings suggest that lower concentrations of vitamin D are independently associated with depressive symptoms in older Korean adults.
本研究旨在探讨老年韩国人群中血清 25-羟维生素 D [25(OH)D] 浓度与抑郁症状之间的关联。
本研究使用了韩国城乡老年人研究的数据，该研究纳入了来自城市和农村社区的 2942 名 65 岁及以上的参与者。在排除了服用抗抑郁药的参与者后，我们对 2853 名参与者（962 名男性和 1891 名女性）进行了横断面分析。血清 25(OH)D 被分析为连续变量和分类变量。抑郁症状使用老年抑郁量表-短式的韩国版本进行评估。分别对男性和女性进行多变量 logistic 回归分析，以检验血清 25(OH)D 与抑郁症状之间的关系。
在男性中，25(OH)D 浓度为 20.0-29.9、10.0-19.9 和 <10.0ng/mL 的参与者发生抑郁症状的 OR（95%CI）分别为 1.74（0.85，3.58）、2.50（1.20，5.18）和 2.81（1.15，6.83）（P 趋势=0.013），与 25(OH)D 浓度≥30.0ng/mL 的参与者相比，校正研究年份、检测月份、年龄、甲状旁腺激素、体重指数、合并症数量、吸烟状况、饮酒量、运动、睡眠时长、收入、教育、同居状况和居住地区后。在女性中，25(OH)D 与抑郁症状之间的关联在调整前后均无统计学意义。
由于横断面研究设计，因果关系不确定。未检查维生素 D 补充剂的摄入和户外活动情况。
我们的研究结果表明，较低的维生素 D 浓度与老年韩国成年人的抑郁症状独立相关。
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