我们能否在危重病中保护肠道？生长因子和其他新方法的作用。
Can we protect the gut in critical illness? The role of growth factors and other novel approaches.
机构信息
Department of Anesthesiology, University of Colorado Denver School of Medicine, 12700 East 19th Avenue, Campus Box 8602, Aurora, CO 80045, USA.
出版信息
Crit Care Clin. 2010 Jul;26(3):549-65, x. doi: 10.1016/j.ccc.2010.04.005.
Abstract
The intestine plays a central role in the pathophysiology of critical illness and is frequently called the "motor" of the systemic inflammatory response. Perturbations to the intestinal barrier can lead to distant organ damage and multiple organ failure. Therefore, identifying ways to preserve intestinal integrity may be of paramount importance. Growth factors and other peptides have emerged as potential tools for modulation of intestinal inflammation and repair due to their roles in cellular proliferation, differentiation, migration, and survival. This review examines the involvement of growth factors and other peptides in intestinal epithelial repair during critical illness and their potential use as therapeutic targets.
摘要
肠道在危重病的病理生理学中起着核心作用，常被称为全身炎症反应的“发动机”。肠道屏障的紊乱可导致远处器官损伤和多器官衰竭。因此，寻找保护肠道完整性的方法可能至关重要。生长因子和其他肽类因其在细胞增殖、分化、迁移和存活中的作用，已成为调节肠道炎症和修复的潜在工具。本文综述了生长因子和其他肽类在危重病期间肠道上皮修复中的作用及其作为治疗靶点的潜在用途。
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