Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center and Albert Einstein College of Medicine, Bronx, NY, USA.
Am J Obstet Gynecol. 2010 Sep;203(3):238.e1-7. doi: 10.1016/j.ajog.2010.06.006.
The objective of the study was to compare 3-dimensional power Doppler (3DPD) of the uteroplacental circulation space (UPCS) in the first trimester between women who develop preeclampsia (PEC) and those who do not and to assess the 3DPD method as a screening tool for PEC.
This was a prospective observational study of singleton pregnancies at 10 weeks 4 days to 13 weeks 6 days. The 3DPD indices, vascularization index (VI), flow index (FI), and vascularization flow index (VFI), were determined on a UPSC sphere biopsy with the virtual organ computer-aided analysis (VOCAL) program.
Of 277 women enrolled, 24 developed PEC. The 3DPD indices were lower in women who developed PEC. The area under the receiver-operating characteristics curve for the prediction of PEC was 78.9%, 77.6%, and 79.6% for VI, FI, and VFI, respectively.
Patients who develop PEC have lower 3DPD indices of their UPCS during the first trimester. Our findings suggest that this ultrasonographic tool has the potential to predict the development of PEC.
本研究旨在比较早孕期发生子痫前期（PEC）和未发生子痫前期孕妇的子宫胎盘循环空间（UPCS）三维能量多普勒（3DPD），并评估 3DPD 方法作为 PEC 的筛查工具。
这是一项对 10 周 4 天至 13 周 6 天的单胎妊娠进行的前瞻性观察性研究。采用虚拟器官计算机辅助分析（VOCAL）程序对 UPCS 球活检进行 3DPD 指数，包括血管化指数（VI）、血流指数（FI）和血管化血流指数（VFI）的测定。
在 277 名入组的孕妇中，有 24 名发生了 PEC。发生 PEC 的孕妇 3DPD 指数较低。VI、FI 和 VFI 预测 PEC 的受试者工作特征曲线下面积分别为 78.9%、77.6%和 79.6%。
早孕期发生 PEC 的患者 UPCS 的 3DPD 指数较低。我们的研究结果表明，这种超声工具有可能预测 PEC 的发生。
