Department of Urology, Kurashiki Central Hospital, Okayama, Japan.
J Urol. 2010 Sep;184(3):1000-4. doi: 10.1016/j.juro.2010.05.038.
Nocturia has a major impact on quality of life and affects numerous aspects of health. Lifestyle modifications are expected to be helpful in improving nocturia. However, the efficacy of this strategy has not been established. We tested the efficacy of nondrug lifestyle measures as a first step in treating nocturia and found factors predictive of the efficacy of the intervention.
We conducted a prospective evaluation of 56 patients treated at 3 hospitals between 2005 and 2009 for symptomatic nocturia. The patients were advised to modify their lifestyle to improve nocturia. Lifestyle modifications consisted of 4 directives of 1) restriction of fluid intake, 2) refraining from excess hours in bed, 3) moderate daily exercise and 4) keeping warm in bed. The frequency volume chart, International Prostate Symptom Score, and Pittsburgh Sleep Quality Index before and 4 weeks after the intervention were used to evaluate the efficacy of the therapy.
Mean nocturnal voids and nocturnal urine volume decreased significantly from 3.6 to 2.7 (p <0.0001) and from 923 to 768 ml (p = 0.0005), respectively. Of the 56 patients 26 (53.1%) showed an improvement of more than 1 episode. This treatment was significantly more effective in patients with a larger 24-hour urine production.
Nondrug lifestyle measures were effective in decreasing the number of nocturia episodes and improving patient quality of life. Patients with polyuria showed a better response to the treatment.
夜尿症对生活质量有重大影响，并影响健康的诸多方面。生活方式的改变预计有助于改善夜尿症。然而，这种策略的疗效尚未确定。我们测试了非药物生活方式措施作为治疗夜尿症的第一步的疗效，并发现了预测干预疗效的因素。
我们对 2005 年至 2009 年间在 3 家医院接受治疗的 56 例有症状夜尿症患者进行了前瞻性评估。建议患者改变生活方式以改善夜尿症。生活方式的改变包括 4 个指令：1）限制液体摄入，2）避免在床上花费过多时间，3）适度的日常运动，4）保持床上温暖。干预前后的频数-体积图、国际前列腺症状评分和匹兹堡睡眠质量指数用于评估治疗的疗效。
平均夜间排尿次数和夜间尿量分别从 3.6 次减少到 2.7 次（p <0.0001）和从 923 毫升减少到 768 毫升（p = 0.0005）。56 例患者中有 26 例（53.1%）夜间排尿次数改善超过 1 次。这种治疗对 24 小时尿量较大的患者更有效。
非药物生活方式措施可有效减少夜尿症发作次数，改善患者生活质量。多尿症患者对治疗的反应更好。
