Neuromuscular Research Center, Department of Biology of Physical Activity, University of Jyväskylä, Jyväskylä, Finland.
FASEB J. 2010 Nov;24(11):4565-74. doi: 10.1096/fj.10-157313. Epub 2010 Jul 19.
A strong link exists between low aerobic exercise capacity and complex metabolic diseases. To probe this linkage, we utilized rat models of low and high intrinsic aerobic endurance running capacity that differ also in the risk for metabolic syndrome. We investigated in skeletal muscle gene-phenotype relationships that connect aerobic endurance capacity with metabolic disease risk factors. The study compared 12 high capacity runners (HCRs) and 12 low capacity runners (LCRs) from generation 18 of selection that differed by 615% for maximal treadmill endurance running capacity. On average, LCRs were heavier and had increased blood glucose, insulin, and triglycerides compared with HCRs. HCRs were higher for resting metabolic rate, voluntary activity, serum high density lipoproteins, muscle capillarity, and mitochondrial area. Bioinformatic analysis of skeletal muscle gene expression data revealed that many genes up-regulated in HCRs were related to oxidative energy metabolism. Seven mean mRNA expression centroids, including oxidative phosphorylation and fatty acid metabolism, correlated significantly with several exercise capacity and disease risk phenotypes. These expression-phenotype correlations, together with diminished skeletal muscle capillarity and mitochondrial area in LCR rats, support the general hypothesis that an inherited intrinsic aerobic capacity can underlie disease risks.
低有氧运动能力与复杂代谢疾病之间存在紧密联系。为了探究这种联系，我们利用低内在有氧耐力跑步能力和高内在有氧耐力跑步能力的大鼠模型进行研究，这些模型在代谢综合征的风险方面也存在差异。我们研究了连接有氧耐力能力与代谢疾病风险因素的骨骼肌表型关系。该研究比较了第 18 代选择的 12 名高能力跑步者（HCRs）和 12 名低能力跑步者（LCRs），他们在最大跑步机耐力跑步能力上的差异为 615%。平均而言，LCRs 比 HCRs 更重，并且血糖、胰岛素和甘油三酯水平更高。HCRs 的静息代谢率、自主活动、血清高密度脂蛋白、肌肉毛细血管和线粒体面积更高。骨骼肌基因表达数据的生物信息学分析表明，HCRs 中上调的许多基因与氧化能量代谢有关。七个平均 mRNA 表达中心点，包括氧化磷酸化和脂肪酸代谢，与几个运动能力和疾病风险表型显著相关。这些表型相关性，以及 LCR 大鼠骨骼肌毛细血管和线粒体面积的减少，支持了一个普遍的假设，即内在的有氧能力可以潜在地导致疾病风险。
