Howard Hughes Medical Institute, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Nat Immunol. 2010 Aug;11(8):674-80. doi: 10.1038/ni.1899. Epub 2010 Jul 20.
As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.
随着更多 CD4 T 细胞分化状态被揭示，其灵活性也开始被认识到。控制 CD4 T 细胞群体可塑性的因素包括细胞状态、克隆性、转录电路和染色质修饰。细胞灵活性的出现可能来自真正灵活的遗传程序，也可能来自异质群体。需要新的工具来定义允许或禁止细胞转变的规则。
