效应 T 细胞可塑性：应对变化环境的灵活性。
Effector T cell plasticity: flexibility in the face of changing circumstances.
机构信息
Howard Hughes Medical Institute, Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
出版信息
Nat Immunol. 2010 Aug;11(8):674-80. doi: 10.1038/ni.1899. Epub 2010 Jul 20.
Abstract
As more states of CD4 T cell differentiation are uncovered, their flexibility is also beginning to be recognized. Components that control the plasticity of CD4 T cell populations include cellular conditions, clonality, transcriptional circuitry and chromatin modifications. Appearance of cellular flexibility may arise from truly flexible genetic programs or, alternatively, from heterogeneous populations. New tools will be needed to define the rules that allow or prohibit cellular transitions.
摘要
随着更多 CD4 T 细胞分化状态被揭示，其灵活性也开始被认识到。控制 CD4 T 细胞群体可塑性的因素包括细胞状态、克隆性、转录电路和染色质修饰。细胞灵活性的出现可能来自真正灵活的遗传程序，也可能来自异质群体。需要新的工具来定义允许或禁止细胞转变的规则。
相似文献
1
Effector T cell plasticity: flexibility in the face of changing circumstances.效应 T 细胞可塑性：应对变化环境的灵活性。
Nat Immunol. 2010 Aug;11(8):674-80. doi: 10.1038/ni.1899. Epub 2010 Jul 20.
2
NF-κB: roles and regulation in different CD4(+) T-cell subsets.NF-κB：不同 CD4(+) T 细胞亚群中的作用和调控。
Immunol Rev. 2013 Mar;252(1):41-51. doi: 10.1111/imr.12033.
3
In Vitro Differentiation of Effector CD4 T Helper Cell Subsets.效应性CD4 T辅助细胞亚群的体外分化
Methods Mol Biol. 2019;1960:75-84. doi: 10.1007/978-1-4939-9167-9_6.
4
CD4 CTL: living up to the challenge.CD4 CTL：迎接挑战。
Semin Immunol. 2013 Nov 15;25(4):273-81. doi: 10.1016/j.smim.2013.10.022.
5
The enigma of CD4-lineage specification.CD4 谱系特化的奥秘。
Eur J Immunol. 2011 Mar;41(3):568-74. doi: 10.1002/eji.201041098. Epub 2011 Feb 10.
6
ARID1a Associates with Lymphoid-Restricted Transcription Factors and Has an Essential Role in T Cell Development.ARID1a 与淋巴系限制转录因子相关联，并在 T 细胞发育中具有重要作用。
J Immunol. 2020 Sep 1;205(5):1419-1432. doi: 10.4049/jimmunol.1900959. Epub 2020 Aug 3.
7
CD4 T-cell subsets and tumor immunity: the helpful and the not-so-helpful.CD4 T 细胞亚群与肿瘤免疫：有益与无益。
Cancer Immunol Res. 2014 Feb;2(2):91-8. doi: 10.1158/2326-6066.CIR-13-0216.
8
Hierarchical regulation of the resting and activated T cell epigenome by major transcription factor families.主要转录因子家族对静息和激活的 T 细胞表观基因组的层次调控。
Nat Immunol. 2022 Jan;23(1):122-134. doi: 10.1038/s41590-021-01086-x. Epub 2021 Dec 22.
9
Helper T-cell differentiation and plasticity: insights from epigenetics.辅助性 T 细胞的分化和可塑性：表观遗传学的启示。
Immunology. 2011 Nov;134(3):235-45. doi: 10.1111/j.1365-2567.2011.03483.x.
10
CD4 T Cell Subsets and Pathways to HIV Latency.CD4 T细胞亚群与HIV潜伏途径
AIDS Res Hum Retroviruses. 2018 Sep;34(9):780-789. doi: 10.1089/AID.2018.0105. Epub 2018 Jul 9.
引用本文的文献
1
Repertoire-based mapping and time-tracking of T helper cell subsets in scRNA-Seq.基于文库的单细胞RNA测序中T辅助细胞亚群的图谱绘制与时间追踪
Front Immunol. 2025 Apr 4;16:1536302. doi: 10.3389/fimmu.2025.1536302. eCollection 2025.
2
Enhanced interpretation of immune cell phenotype and function through a rhesus macaque single-cell atlas.通过恒河猴单细胞图谱增强对免疫细胞表型和功能的解读。
Cell Genom. 2025 May 14;5(5):100849. doi: 10.1016/j.xgen.2025.100849. Epub 2025 Apr 14.
3
Using Specific Reporter Mice to Assess CD4 T Cell Transdifferentiation.使用特定报告基因小鼠评估CD4 T细胞转分化。
Methods Mol Biol. 2025;2904:125-132. doi: 10.1007/978-1-0716-4414-0_9.
4
Immunology and treatments of fatty liver disease.脂肪肝疾病的免疫学与治疗方法
Arch Toxicol. 2025 Jan;99(1):127-152. doi: 10.1007/s00204-024-03920-1. Epub 2024 Dec 18.
5
An updated review of HSV-1 infection-associated diseases and treatment, vaccine development, and vector therapy application.单纯疱疹病毒 1 型感染相关疾病的治疗及疫苗研发、载体治疗应用的最新综述
Virulence. 2024 Dec;15(1):2425744. doi: 10.1080/21505594.2024.2425744. Epub 2024 Nov 13.
6
Immunological mechanisms in steatotic liver diseases: An overview and clinical perspectives.免疫机制在脂肪性肝病中的作用：综述与临床展望。
Clin Mol Hepatol. 2024 Oct;30(4):620-648. doi: 10.3350/cmh.2024.0315. Epub 2024 Jul 11.
7
Plasticity and lineage commitment of individual T1 cells are determined by stable T-bet expression quantities.单个 T1 细胞的可塑性和谱系决定由稳定的 T-bet 表达量决定。
Sci Adv. 2024 Jun 7;10(23):eadk2693. doi: 10.1126/sciadv.adk2693. Epub 2024 Jun 5.
8
The PD-1/PD-L1 Axis in the Biology of MASLD.PD-1/PD-L1 轴在 MASLD 生物学中的作用。
Int J Mol Sci. 2024 Mar 25;25(7):3671. doi: 10.3390/ijms25073671.
9
T-helper cells flexibility: the possibility of reprogramming T cells fate.辅助性 T 细胞的灵活性：重编程 T 细胞命运的可能性。
Front Immunol. 2023 Nov 1;14:1284178. doi: 10.3389/fimmu.2023.1284178. eCollection 2023.
10
Both Horatio and Polonius: Innate Lymphoid Cells in Tissue Homeostasis and Repair.贺睿和波洛纽斯：组织稳态和修复中的固有淋巴细胞。
Immunohorizons. 2023 Nov 1;7(11):729-736. doi: 10.4049/immunohorizons.2300053.
本文引用的文献
1
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage.细胞因子和转录因子基因座的表观遗传不稳定性是 Th17 细胞谱系可塑性的基础。
Immunity. 2010 May 28;32(5):616-27. doi: 10.1016/j.immuni.2010.04.016. Epub 2010 May 13.
2
Partitioning of histone H3-H4 tetramers during DNA replication-dependent chromatin assembly.组蛋白 H3-H4 四聚体在 DNA 复制依赖性染色质组装过程中的分配。
Science. 2010 Apr 2;328(5974):94-8. doi: 10.1126/science.1178994.
3
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.干扰素直接诱导 Th2 细胞重编程，产生具有 Th2 和 Th1 细胞功能的稳定 GATA-3(+)T-bet(+)细胞亚群。
Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.
4
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate.调控性 T 细胞命运中 Foxp3 基因中保守非编码 DNA 元件的作用。
Nature. 2010 Feb 11;463(7282):808-12. doi: 10.1038/nature08750. Epub 2010 Jan 13.
5
Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors.分析白细胞介素-21 诱导的 Prdm1 基因调控揭示了 STAT3 和 IRF4 转录因子的功能合作。
Immunity. 2009 Dec 18;31(6):941-52. doi: 10.1016/j.immuni.2009.10.008.
6
Decrease of Foxp3+ Treg cell number and acquisition of effector cell phenotype during lethal infection.致死性感染期间Foxp3 +调节性T细胞数量减少及效应细胞表型的获得。
Immunity. 2009 Nov 20;31(5):772-86. doi: 10.1016/j.immuni.2009.10.001. Epub 2009 Nov 5.
7
Histones: annotating chromatin.组蛋白：对染色质进行注释。
Annu Rev Genet. 2009;43:559-99. doi: 10.1146/annurev.genet.032608.103928.
8
Runx proteins regulate Foxp3 expression.Runx蛋白调节Foxp3的表达。
J Exp Med. 2009 Oct 26;206(11):2329-37. doi: 10.1084/jem.20090226. Epub 2009 Oct 19.
9
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.CD4+ 调节性 T 细胞通过 Stat3 依赖性方式控制 TH17 反应。
Science. 2009 Nov 13;326(5955):986-91. doi: 10.1126/science.1172702. Epub 2009 Oct 1.
10
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes.全基因组范围内对组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）的图谱绘制揭示了它们在活跃基因和非活跃基因中的不同功能。
Cell. 2009 Sep 4;138(5):1019-31. doi: 10.1016/j.cell.2009.06.049. Epub 2009 Aug 20.
Zotero 插件