Obadia J F, Brachet A, Lancon J P, Raoux M H, Brenot R, David M
Service de chirurgie cardiovasculaire et angiologie, hôpital du Bocage, Dijon.
Arch Mal Coeur Vaiss. 1991 Apr;84(4):569-72.
Aortic stenosis is found in 15 to 25% of patients with gastrointestinal angiodysplasia. The usual treatment for haemorrhagic angiodysplasia associated with aortic stenosis is the same as for other types of gastrointestinal angiodysplasias: segmental intestinal resection, electrocoagulation and laser photocoagulation. The authors report the case of a 73 year old woman with a long history of gastro-intestinal bleeding and chronic anaemia requiring a number of hospital admissions for blood transfusions. The cause of this bleeding remained obscure for many years, as it was initially thought to be due to portal hypertension complicating cyrrhosis and a surgical porto-caval shunt was performed. Later, angiodysplasia of the colon was recognised and a segmental colonic resection was performed. These two surgical procedures had no effect on the chronic bleeding and finally the patient was referred for a gram negative endocarditis complicating aortic stenosis, previously considered to be non-surgical. After controlling the infection, the patient was sent for surgery of the aortic valve disease with mitral regurgitation in view of progressive degradation of left ventricular function. A double valve replacement with bioprostheses was undertaken with no complication. Finally, three years now after valve replacement, no further bleeding has occurred and control colonoscopy is normal. In the light of this case and a review of the literature of about 30 similar cases, the physiopathology and management of these patients is discussed with respect to the choice of valve prosthesis and the attitude to anticoagulant therapy. These observations suggest that in the presence of valvular heart disease at a surgical stage associated to an angiodysplasia, it is preferable to propose valve surgery to start with. Gastro-intestinal surgery is only indicated if haemorrhage persists after a period of observation.
在15%至25%的胃肠道血管发育异常患者中可发现主动脉瓣狭窄。与主动脉瓣狭窄相关的出血性血管发育异常的常规治疗方法与其他类型的胃肠道血管发育异常相同:节段性肠切除术、电凝术和激光光凝术。作者报告了一例73岁女性患者,该患者有长期胃肠道出血和慢性贫血病史,因需要多次住院输血。多年来,这种出血的原因一直不明,最初认为是由于肝硬化并发门静脉高压,并进行了手术门腔分流术。后来,发现了结肠血管发育异常并进行了节段性结肠切除术。这两种外科手术对慢性出血均无效果,最终该患者因主动脉瓣狭窄并发革兰氏阴性心内膜炎而前来就诊,此前认为该疾病无法进行手术治疗。在控制感染后,鉴于左心室功能逐渐恶化,该患者被送去进行主动脉瓣疾病合并二尖瓣反流的手术。进行了生物假体双瓣膜置换术,未出现并发症。最后,在瓣膜置换三年后,未再发生出血,结肠镜检查结果正常。根据该病例以及对约30例类似病例的文献回顾,就瓣膜假体的选择和抗凝治疗的态度,对这些患者的生理病理学和治疗方法进行了讨论。这些观察结果表明,在存在与血管发育异常相关的手术阶段瓣膜性心脏病的情况下,最好首先建议进行瓣膜手术。只有在经过一段时间观察后出血仍持续时,才考虑进行胃肠道手术。