Biopharmaceutics and Parenteral Delivery, Pharmaceutical Sciences, Merck Sharp & Dohme Corp., West Point, PA 19486, USA.
Expert Opin Drug Deliv. 2010 Aug;7(8):977-92. doi: 10.1517/17425247.2010.503953.
Psoriasis is one of the most common human skin diseases. Topical therapy forms the cornerstone in the management of mild-to-moderate psoriasis. Topical therapies are also used as adjunctive to systemic therapy in moderate and severe forms of the disease.
In this review, an overview of psoriasis pathogenesis, new topical medications for psoriasis, new targets and molecules, combination topical therapies and combination of topical and phototherapy is provided. Over the past decade several efficacious and acceptable treatment options have emerged from the age-old therapies. The development of sophisticated formulation options has led to an enhancement in the rate and extent of drug delivery across the skin, increasing therapeutic value and improving patient compliance.
Readers will learn about monotherapy and combination topical products as well as new topical drug delivery technology to achieve optimal clinical outcomes. This review will highlight the need to generate more dermal pharmacokinetic data for better understanding of the impact of formulation change on skin pharmacokinetics to help design improved topical drug delivery systems.
New topical formulations have the potential to achieve better efficacy with improved safety profile.
银屑病是最常见的人类皮肤疾病之一。局部治疗是治疗轻中度银屑病的基础。局部治疗也被用作中度和重度疾病的系统治疗的辅助手段。
在这篇综述中，提供了银屑病发病机制、新的银屑病局部治疗药物、新的靶点和分子、联合局部治疗和局部与光疗联合的概述。在过去的十年中，从古老的治疗方法中出现了一些有效且可接受的治疗选择。复杂配方选择的发展导致药物在皮肤中的传递速度和程度提高，从而提高了治疗价值并提高了患者的依从性。
读者将了解单药治疗和联合局部产品以及新的局部药物输送技术，以实现最佳的临床效果。这篇综述强调需要生成更多的皮肤药代动力学数据，以更好地了解配方变化对皮肤药代动力学的影响，从而帮助设计改进的局部药物输送系统。
新的局部制剂有可能在提高安全性的同时提高疗效。
