用于银屑病局部治疗的药物递送与制剂
Drug delivery and formulations for the topical treatment of psoriasis.
作者信息
Su Yu-Han, Fang Jia-You
机构信息
Chang Gung University, Pharmaceutics Laboratory, Graduate Institute of Natural Products, 259 Wen-Hwa 1st Road, Kweishan, Taoyuan 333, Taiwan.
出版信息
Expert Opin Drug Deliv. 2008 Feb;5(2):235-49. doi: 10.1517/17425247.5.2.235.
BACKGROUND
Psoriasis is one of the most common human skin diseases. It is characterised by excessive growth and aberrant differentiation of corneocytes, but is fully reversible with appropriate therapy.
OBJECTIVE
There are many drug therapies for psoriasis via the topical delivery route. This review describes the topically applied drugs used to treat psoriasis.
METHODS
Formulations to carry or encapsulate these drugs are introduced in this review. Enhancing approaches such as liposome inclusion, iontophoresis and laser are also discussed.
CONCLUSION
This review summarises developments in the design of formulations in the area of topical drug delivery for treating psoriasis.
背景
银屑病是人类最常见的皮肤病之一。其特征为角质形成细胞过度生长和异常分化，但通过适当治疗可完全逆转。
目的
有多种通过局部给药途径治疗银屑病的药物疗法。本综述描述了用于治疗银屑病的局部应用药物。
方法
本综述介绍了携带或包裹这些药物的制剂。还讨论了脂质体包封、离子导入和激光等增强方法。
结论
本综述总结了用于治疗银屑病的局部药物递送领域制剂设计的进展。
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