University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany.
Expert Rev Anticancer Ther. 2010 Jul;10(7):1115-24. doi: 10.1586/era.10.90.
Borderline ovarian tumors (BOTs) are epithelial tumors of the ovaries characterized by cellular proliferation and nuclear atypia but without an infiltrative growth pattern. As they frequently affect younger patients the clinical management is complicated by considerations such as preserving fertility and reducing postoperative morbidity. Over the past several decades surgical therapy has shifted from a radical approach to more conservative treatment. There are various modes of surgery applied to the patients. All these developments have to be considered from an oncologic standpoint as BOTs represent a potentially malignant disease. Oncologic safety, as well as patients' desires and expectations, have to be balanced to reach the most appropriate treatment for BOTs. For this reason current literature will be discussed in this review to give a thorough overview of this topic and to develop recommendations for the surgical management of these patients. Open questions will be identified to elaborate the need for future surveys and research.
交界性卵巢肿瘤（BOTs）是一种卵巢上皮性肿瘤，其特征为细胞增殖和核异型性，但无浸润性生长模式。由于它们常影响年轻患者，因此在临床管理中需要考虑到保留生育能力和降低术后发病率等因素，这使得临床管理变得复杂。在过去几十年中，手术治疗已经从激进方法转向更为保守的治疗。目前针对患者有多种手术模式。所有这些发展都必须从肿瘤学的角度来考虑，因为 BOTs 代表一种潜在的恶性疾病。为了达到最适合 BOTs 的治疗方法，需要平衡肿瘤学安全性以及患者的愿望和期望。出于这个原因，本综述将讨论当前的文献，以全面概述这个主题，并为这些患者的手术管理提出建议。将确定未解决的问题，以阐明未来调查和研究的必要性。
