Lopez J S, Price F W, Whitcup S M, Li Q, de Smet M, Chan C C
Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Md 20892.
Arch Ophthalmol. 1991 Jul;109(7):988-92. doi: 10.1001/archopht.1991.01080070100045.
Lamellar keratoplasty specimens from a patient with Terrien's marginal degeneration and a patient with Mooren's ulcer were compared using routine histopathologic and immunohistochemical staining with an avidin-biotin-peroxidase complex. Less than 25% of the resident cells in the Terrien's marginal degeneration specimen expressed major histocompatibility class II antigens compared with 75% to 100% of the resident cells in the Mooren's ulcer specimen. The ratio of CD4 cells (T-helper/inducer) to CD8 cells (T-suppressor/cytotoxic cells) in the Terrien's marginal degeneration specimen was almost 1:1 compared with 24:1 in the Mooren's ulcer specimen. In addition, less than 5% of the infiltrating cells from the Terrien's marginal degeneration specimen stained positive for CD22 (B cells), compared with 25% to 50% from the Mooren's ulcer specimen. These data may help explain why Terrien's marginal degeneration runs a more benign course than does Mooren's ulcer and provides a rationale for the use of immunosuppressive drugs to treat Mooren's ulcer.
使用抗生物素蛋白-生物素-过氧化物酶复合物进行常规组织病理学和免疫组织化学染色，对一名患有泰里恩边缘性角膜变性的患者和一名患有蚕蚀性角膜溃疡的患者的板层角膜移植标本进行了比较。在泰里恩边缘性角膜变性标本中，不到25%的驻留细胞表达主要组织相容性复合体II类抗原，而在蚕蚀性角膜溃疡标本中，这一比例为75%至100%。泰里恩边缘性角膜变性标本中CD4细胞（辅助性/诱导性T细胞）与CD8细胞（抑制性/细胞毒性T细胞）的比例约为1:1，而在蚕蚀性角膜溃疡标本中该比例为24:1。此外，泰里恩边缘性角膜变性标本中不到5%的浸润细胞CD22染色呈阳性（B细胞），而蚕蚀性角膜溃疡标本中的这一比例为25%至50%。这些数据可能有助于解释为什么泰里恩边缘性角膜变性的病程比蚕蚀性角膜溃疡更为良性，并为使用免疫抑制药物治疗蚕蚀性角膜溃疡提供了理论依据。
