Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Pharm Biol. 2010 Feb;48(2):177-81. doi: 10.3109/13880200903062663.
The naringinase-treated methanol extract of Sophora japonica L. (Fabaceae) seeds showed potent estrogen agonist activity. Through bioassay-guided isolation of the main active constituents from the naringinase-treated methanol extract of S. japonica, the aglycones genistein and kaempferol were found to be the main phytoestrogens in the naringinase-treated extract. In addition, kaempferol was nearly equipotent to genistein as an estrogen agonist. Concerning the compounds isolated from the untreated methanol extract, sophoricoside showed weak estrogenic activity on ERbeta only.
经处理的槐属甲醇提取物（豆科）的柚皮苷酶显示出强大的雌激素激动剂活性。通过从槐属甲醇提取物中对主要活性成分进行生物测定指导分离，发现处理后的提取物中的主要植物雌激素为染料木素和山奈酚的苷元。此外，山奈酚作为雌激素激动剂几乎与染料木素有同等效力。关于从未处理的甲醇提取物中分离出的化合物，槐属糖苷仅对 ERbeta 显示出较弱的雌激素活性。
