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视网膜和视路的发育。

Development of the retina and optic pathway.

作者信息

Reese Benjamin E

机构信息

Neuroscience Research Institute and Department of Psychology, University of California at Santa Barbara, Santa Barbara, CA 93106-5060, USA.

出版信息

Vision Res. 2011 Apr 13;51(7):613-32. doi: 10.1016/j.visres.2010.07.010. Epub 2010 Jul 18.

Abstract

Our understanding of the development of the retina and visual pathways has seen enormous advances during the past 25years. New imaging technologies, coupled with advances in molecular biology, have permitted a fuller appreciation of the histotypical events associated with proliferation, fate determination, migration, differentiation, pathway navigation, target innervation, synaptogenesis and cell death, and in many instances, in understanding the genetic, molecular, cellular and activity-dependent mechanisms underlying those developmental changes. The present review considers those advances associated with the lineal relationships between retinal nerve cells, the production of retinal nerve cell diversity, the migration, patterning and differentiation of different types of retinal nerve cells, the determinants of the decussation pattern at the optic chiasm, the formation of the retinotopic map, and the establishment of ocular domains within the thalamus.

摘要

在过去25年里,我们对视网膜及视觉通路发育的理解取得了巨大进展。新的成像技术,结合分子生物学的进步,使我们能够更全面地认识与增殖、命运决定、迁移、分化、通路导航、靶标神经支配、突触形成和细胞死亡相关的组织学典型事件,并且在许多情况下,有助于理解这些发育变化背后的遗传、分子、细胞和活动依赖机制。本综述探讨了与视网膜神经细胞之间的线性关系、视网膜神经细胞多样性的产生、不同类型视网膜神经细胞的迁移、模式形成和分化、视交叉处交叉模式的决定因素、视网膜拓扑图的形成以及丘脑内眼区的建立相关的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/08df/2974959/3cf638bc7905/nihms224416f1.jpg

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