Luong Amber, Cheung Esther J, Citardi Martin J, Batra Pete S
Department of Otorhinolaryngology-Head and Neck Surgery and Texas Sinus Institute, University of Texas Medical School, Houston, TX 77030, USA.
Otolaryngol Head Neck Surg. 2010 Aug;143(2):284-9. doi: 10.1016/j.otohns.2010.03.030.
Optical rhinometry is a new method that quantifies light extinction in optical density to assess nasal blood volume as a measure of nasal patency. The purpose of this study is to evaluate optical rhinometry as an objective evaluation of nasal patency using nasal provocation testing with histamine and oxymetazoline.
Prospective pilot.
Academic tertiary rhinologic practice.
Convenience sample of five adult subjects with allergic rhinitis and five adult normal subjects who underwent challenge with histamine and oxymetazoline. Patients underwent challenge with increasing concentrations of histamine to determine the amount of histamine needed to cause a positive optical rhinometry reading. The same subjects then underwent histamine challenge with this amount followed by oxymetazoline. Nasal patency was assessed subjectively after each challenge with the visual analog scale.
The median histamine amount needed to cause a positive response was statistically lower in allergic rhinitis as compared with nonallergic subjects at 150 microg and 300 microg, respectively (P = 0.04). When comparing the optical rhinometry with subjective nasal congestion after histamine and oxymetazoline challenges, there was a statistically significant correlation with r = 0.79 (P = 0.00003).
This initial study demonstrates a correlation between subjective symptoms of nasal patency and objective measurements with the optical rhinometer. Less histamine amount necessary to incite nasal congestion in allergic rhinitis suggests that these patients may be primed to the effects of histamine. These preliminary data suggest that optical rhinometry is able to assess changes in nasal patency during challenges with histamine and oxymetazoline.
光学鼻测量法是一种通过量化光密度中的光衰减来评估鼻腔血容量以衡量鼻通畅度的新方法。本研究的目的是使用组胺和羟甲唑啉进行鼻激发试验，评估光学鼻测量法作为鼻通畅度的客观评估方法。
前瞻性试点研究。
学术性三级鼻科诊所。
选取五名患有过敏性鼻炎的成年受试者和五名成年正常受试者作为便利样本，对其进行组胺和羟甲唑啉激发试验。患者接受递增浓度组胺激发试验，以确定引起光学鼻测量法阳性读数所需的组胺量。然后，相同受试者接受该剂量组胺激发试验，随后进行羟甲唑啉激发试验。每次激发试验后，使用视觉模拟量表主观评估鼻通畅度。
引起阳性反应所需的组胺量中位数，在过敏性鼻炎患者中分别为150微克和300微克，与非过敏性受试者相比，差异有统计学意义（P = 0.04）。在组胺和羟甲唑啉激发试验后，将光学鼻测量法与主观鼻充血情况进行比较，两者存在统计学显著相关性，r = 0.79（P = 0.00003）。
这项初步研究表明，鼻通畅度的主观症状与光学鼻测量仪的客观测量结果之间存在相关性。过敏性鼻炎患者引起鼻充血所需的组胺量较少，表明这些患者可能对组胺的作用更为敏感。这些初步数据表明，光学鼻测量法能够评估组胺和羟甲唑啉激发试验期间鼻通畅度的变化。
