Gantenbein Andreas R, Riederer Franz, Mathys Jan, Biethahn Silke, Gossrau Gudrun, Waldvogel Daniel, Sándor Peter S
Department of Neurology, University Hospital Zurich, Switzerland.
Cephalalgia. 2011 Jan;31(2):206-12. doi: 10.1177/0333102410377361. Epub 2010 Jul 20.
Acute confusional migraine (ACM) is considered a rare migraine variant primarily seen in children and adolescents.
We present a series of eight adults and two adolescents suffering from migraine attacks associated with transient confusional states.
Eight patients reported two or more such attacks. One of them reported mild head trauma in the past. One patient reported mild head trauma as a possible trigger. Further investigations were unremarkable in all patients and did not suggest underlying structural abnormalities, epilepsy or cerebrovascular disease. In none of these patients did we find another cause to explain the observed phenomenon.
Based on this series of patients, we suggest expanding the concept of confusional migraine from the paediatric population to adults. The temporal course of the confusion as well as the association with visual and other aura symptoms suggest cortical spreading depression as the underlying pathophysiology.
急性混淆型偏头痛（ACM）被认为是一种罕见的偏头痛变体，主要见于儿童和青少年。
我们报告了一系列共10例患者，其中8例为成年人，2例为青少年，他们均患有与短暂混淆状态相关的偏头痛发作。
8例患者报告有两次或更多次此类发作。其中1例报告过去有轻度头部外伤。1例患者报告轻度头部外伤可能是诱因。所有患者的进一步检查均无异常，未提示潜在的结构异常、癫痫或脑血管疾病。在这些患者中，我们未发现其他原因可解释所观察到的现象。
基于这一系列患者，我们建议将混淆型偏头痛的概念从儿科人群扩展到成年人。混淆状态的时间进程以及与视觉和其他先兆症状的关联提示皮层扩散性抑制是潜在的病理生理学机制。
