Li N
Qingdao Medical College.
Zhonghua Er Bi Yan Hou Ke Za Zhi. 1991;26(2):85-7, 125.
The nasal respiratory mucosa of thirty-eight rabbits were studied with histopathological method. Among those rabbits, sixteen were injected with estrogen, sixteen androgen, and the other eight as control. The nasal respiratory mucosa of all animals were observed under light microscope, seven of them were observed under transmission electron microscope. Animals injected with estrogen showed the following changes: the nasal respiratory mucosa became thick. The submucosa was spongy and edematous, the capillaries were dilated and congested. The tunical glands were hyperplastic and hyperactive. Numerous newly-produced collagen fibrils deposited in the lamina propria. After one or two months of drug administration, some thick-walled arterioles appeared. The effect of androgen on nasal mucosa of the animals was similar to that of estrogen in some respects, but the effect on the vessels was slight, no newly-produced collagen fibril deposition. Many epithelial cells and glandular cells were degenerated. The effect on nasal respiratory mucosa between male and female animals seemed to be different.
采用组织病理学方法对38只家兔的鼻呼吸黏膜进行了研究。其中16只注射雌激素，16只注射雄激素，另外8只作为对照。所有动物的鼻呼吸黏膜均在光学显微镜下观察，7只在透射电子显微镜下观察。注射雌激素的动物出现以下变化：鼻呼吸黏膜增厚。黏膜下层呈海绵状且水肿，毛细血管扩张充血。管泡状腺体增生且活跃。大量新产生的胶原纤维沉积于固有层。给药一两个月后，出现一些厚壁小动脉。雄激素对动物鼻黏膜的作用在某些方面与雌激素相似，但对血管的作用轻微，无新产生的胶原纤维沉积。许多上皮细胞和腺细胞发生变性。雄性和雌性动物对鼻呼吸黏膜的影响似乎有所不同。
