School of Education Science, Minnan Normal University, Zhangzhou, Fujian 363000, China.
Brain and Cognitive Neuroscience Research Center, Liaoning Normal University, Dalian, Liaoning 116029, China.
Neural Plast. 2021 Mar 12;2021:8529613. doi: 10.1155/2021/8529613. eCollection 2021.
Sensory gating is a neurophysiological measure of inhibition that is characterized by a reduction in the P, N, and P event-related potentials to a repeated identical stimulus. It was proposed that abnormal sensory gating is involved in the neural pathological basis of some severe mental disorders. Since then, the prevailing application of sensory gating measures has been in the study of neuropathology associated with schizophrenia and so on. However, sensory gating is not only trait-like but can be also state-like, and measures of sensory gating seemed to be affected by several factors in healthy subjects. The objective of this work was to clarify the roles of acute stress and gender in sensory gating. Data showed acute stress impaired inhibition of P to the second click in the paired-click paradigm without effects on sensory registration leading to worse P sensory gating and disrupted attention allocation reflected by attenuated P responses than control condition, without gender effects. As for N and P gating, women showed slightly better than men without effects of acute stress. Data also showed slightly larger N amplitudes across clicks and significant larger P amplitude to the first click for women, suggesting that women might be more alert than men.
感觉门控是一种神经生理抑制的测量方法，其特征是对重复的相同刺激的 P、N 和 P 事件相关电位的降低。有人提出，异常的感觉门控与一些严重精神障碍的神经病理基础有关。从那时起，感觉门控测量的主要应用一直是在与精神分裂症等相关的神经病理学研究中。然而，感觉门控不仅具有特质性，而且还具有状态性，并且感觉门控的测量似乎受到健康受试者中几个因素的影响。本工作的目的是阐明急性应激和性别在感觉门控中的作用。数据显示，急性应激会损害在成对点击范式中对第二个点击的 P 的抑制，但对感觉登记没有影响，导致 P 感觉门控更差，注意力分配受到干扰，表现为 P 反应减弱，而对照组没有性别影响。对于 N 和 P 门控，女性的表现略优于男性，而急性应激没有影响。数据还显示，女性在各次点击中 N 波幅稍大，对第一次点击的 P 波幅明显增大，这表明女性可能比男性更警觉。
