一种导致酵母中异-2-细胞色素c过量产生的染色体易位。
A chromosomal translocation causing overproduction of iso-2-cytochrome c in yeast.
作者信息
Sherman F, Helms C
出版信息
Genetics. 1978 Apr;88(4 Pt 1):689-707.
Abstract
The CYC7-1 mutation in the yeast Saccharomyces cerevisiae causes the production of approximately 30 times the normal amount of iso-2-cytochrome c. Genetic analysis established that the CYC7-1 mutation is a reciprocal translocation involving the left arm of chromosome V and the right arm of chromosome XVI. The chromosome V arm was broken adjacent to the gene CYC7, which determines the primary structure of iso-2-cytochrome c, and this fragment containing the CYC7 gene was joined to the segment of chromosome XVI. It appears as though the elevation of iso-2-cytochrome c is caused by an abnormal controlling region adjacent to the structural region of the CYC7 gene.
摘要
酿酒酵母中的CYC7-1突变导致异-2-细胞色素c的产量约为正常产量的30倍。遗传分析表明，CYC7-1突变是一种相互易位，涉及第五条染色体的左臂和第十六条染色体的右臂。第五条染色体的臂在决定异-2-细胞色素c一级结构的CYC7基因附近断裂，含有CYC7基因的这一片段与第十六条染色体的片段相连。似乎异-2-细胞色素c的升高是由CYC7基因结构区域附近的异常控制区域引起的。
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