决定酵母同工-2-细胞色素c的CYC7基因的染色体定位：结构和调控区域
Chromosome mapping of the CYC7 gene determining yeast iso-2-cytochrome c: structural and regulatory regions.
作者信息
Sherman F, Stewart J W, Helms C, Downie J A
出版信息
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1437-41. doi: 10.1073/pnas.75.3.1437.
Abstract
The primary structures of iso-1-cytochrome c and iso-2-cytochrome c in the yeast Saccharomyces cerevisiae are determined by the genes CYC1 and CYC7, respectively. The CYC1 locus was previously shown to be on the right arm of chromosome X, and the CYC7 locus is shown in this investigation to be on the left arm of chromosome V closely linked to the min1 and mak10 markers. The CYC7 locus appears to be composed of a structural region and a regulatory region. Mutations in the structural region can cause a deficiency or alteration of iso-2-cytochrome c, whereas mutations in the regulatory region can cause increases in the amount of iso-2-cytochrome c. Single-site gene conversion, occurring at a relatively high frequency of approximately 4%, caused intragenic recombination of a mutational site in the structural region and a mutational site in the regulatory region, enabling us to suggest the order of the sites in relationship to other markers on the chromosome.
摘要
酿酒酵母中同工酶-1-细胞色素c和同工酶-2-细胞色素c的一级结构分别由CYC1基因和CYC7基因决定。CYC1基因座先前已证明位于X染色体的右臂上，而CYC7基因座在本研究中显示位于V染色体的左臂上，与min1和mak10标记紧密连锁。CYC7基因座似乎由一个结构区域和一个调控区域组成。结构区域中的突变可导致同工酶-2-细胞色素c的缺陷或改变，而调控区域中的突变可导致同工酶-2-细胞色素c的量增加。单一位点基因转换以约4%的相对高频发生，导致结构区域中的突变位点与调控区域中的突变位点发生基因内重组，使我们能够推测这些位点与染色体上其他标记的关系顺序。
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