Julow Jeno
Szent János Hospital, Department of Neurosurgery, Budapest.
Ideggyogy Sz. 2010 May 30;63(5-6):164-9.
The paper is the summary of mostly published works of the clinical results of intracavitary Yttrium-90 colloid irradiation of recurrent cystic craniopharyngiomas, and Iodine-125 interstitial irradiation of gliomas, pinealomas, brainstem tumors, recurrent meningeomas, solid craniopharyngiomas and metastases. It concisely demonstrates the usefulness of image fusion in the verification of isotope seeds and catheters, the comparison of 125 Iodine stereotactic brachytherapy and LINAC radiosurgery modalities on physical dose distribution and radiobiological efficacy, and the analysis of volumetric changes after interstitial irradiation of gliomas. Results of the immunohistochemical study deal with the role of microglia/macrophage system in the tissue response to 1-125 interstitial brachytherapy of cerebral gliomas. Due to financial reasons, gamma knife and Linac are not available to many countries and neurosurgical institutes. In the absence of the above mentioned radiosurgical methods, we have shown brachytherapy as an alternative solution in the treatment of different types of inoperable or recurrent brain tumors. The observed results may be noticable at LINAC and gamma knife irradiation too.
本文是关于复发性囊性颅咽管瘤腔内钇-90胶体照射、胶质瘤、松果体瘤、脑干肿瘤、复发性脑膜瘤、实性颅咽管瘤及转移瘤碘-125间质照射临床结果的大部分已发表作品的总结。它简要展示了图像融合在同位素籽源和导管验证中的作用、125碘立体定向近距离放疗与直线加速器放射外科模式在物理剂量分布和放射生物学疗效方面的比较，以及胶质瘤间质照射后体积变化的分析。免疫组化研究结果涉及小胶质细胞/巨噬细胞系统在脑胶质瘤1-125间质近距离放疗组织反应中的作用。由于经济原因，许多国家和神经外科机构无法使用伽马刀和直线加速器。在缺乏上述放射外科方法的情况下，我们已表明近距离放疗是治疗不同类型无法手术或复发性脑肿瘤的替代解决方案。在直线加速器和伽马刀照射中也可能观察到类似结果。
