沙眼大规模抗生素分发停止后肺炎球菌耐药性的下降。
The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma.
机构信息
FI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California 94143-0944, USA.
出版信息
Clin Infect Dis. 2010 Sep 1;51(5):571-4. doi: 10.1086/655697.
After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P <.001 ) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.
在埃塞俄比亚社区进行了 6 次每两年一次的口服阿奇霉素沙眼大规模分发后，1-5 岁儿童鼻咽部肺炎链球菌分离株对大环内酯类药物的耐药率为 76.8%（95%置信区间[CI]，66.3%-85.1%）。在最后一次阿奇霉素治疗后 12 个月和 24 个月时，耐药率分别下降至 30.6%（95%CI，18.8%-40.4%；P<0.001）和 20.8%（95%CI，12.7%-30.7%；P<0.001）。抗生素压力消除后，大环内酯类药物的耐药性会下降。
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