Leanderson P, Sahle W
Department of Occupational and Environmental Medicine, Faculty of Health Sciences, Linköping University, S-581 85 Linköping, Sweden.
Toxicol In Vitro. 1995 Apr;9(2):175-83. doi: 10.1016/0887-2333(94)00197-3.
Occupational exposure to hard metal dust may cause interstitial pulmonary fibrosis and asthma. The cause of asthma is well established, whereas the cause of lung fibrosis is still under debate. Recently, slightly reduced airborne tunsten oxide fibres, the role of which in hard metal pneumoconiosis has never been accounted for, were detected in an air sample from a hard metal production plant. In this study, the capacity to generate hydroxyl radicals, toxicity to cultured human lung cells and haemolytic activity of tungsten oxide fibres were compared with crocidolite asbestos fibres. The results show (a) that tungsten oxide fibres can generate hydroxyl radicals, and (b) that tunsten oxide fibres were more cytotoxic to human lung cells than was crocidolite, but (c) that the haemolytic activity of tungsten oxide fibres was lower than for crocidolite.
职业接触硬质金属粉尘可能会导致间质性肺纤维化和哮喘。哮喘的病因已明确，而肺纤维化的病因仍存在争议。最近，在一家硬质金属生产厂的空气样本中检测到空气中的氧化钨纤维略有减少，其在硬质金属尘肺中的作用从未得到解释。在本研究中，将氧化钨纤维产生羟基自由基的能力、对培养的人肺细胞的毒性以及溶血活性与青石棉纤维进行了比较。结果表明：（a）氧化钨纤维可产生羟基自由基；（b）氧化钨纤维对人肺细胞的细胞毒性比青石棉更大；但（c）氧化钨纤维的溶血活性低于青石棉。
