白细胞介素-12 作为诱导保护性抗体应答的佐剂。
Interleukin-12 as an adjuvant for induction of protective antibody responses.
机构信息
Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY 12208, USA.
出版信息
Cytokine. 2010 Oct-Nov;52(1-2):102-7. doi: 10.1016/j.cyto.2010.06.011. Epub 2010 Jul 22.
Abstract
Interleukin (IL)-12 is a pivotal cytokine that strongly stimulates Th1-associated cellular immunity. It is now recognized that IL-12 also activates humoral immunity to both T-dependent and T-independent antigens. This has let to considerable interest in exploiting IL-12 as a vaccine adjuvant for protection against various bacterial and viral pathogens, particularly in the lung. Studies examining the efficacy of IL-12-mediated effects on protective antibody response in the mouse model are summarized in this review.
摘要
白细胞介素（IL）-12 是一种关键的细胞因子，可强烈刺激 Th1 相关的细胞免疫。现在人们已经认识到，IL-12 还能激活针对 T 依赖性和 T 非依赖性抗原的体液免疫。这使得人们对将 IL-12 用作疫苗佐剂以预防各种细菌和病毒病原体，特别是肺部病原体产生了浓厚的兴趣。本文总结了在小鼠模型中研究 IL-12 对保护性抗体应答的介导作用的功效的研究。
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