肺鼠疫疫苗研发中的当前挑战。
Current challenges in the development of vaccines for pneumonic plague.
作者信息
Smiley Stephen T
机构信息
Trudeau Institute, 154 Algonquin Avenue, Saranac Lake, NY 12983, USA.
出版信息
Expert Rev Vaccines. 2008 Mar;7(2):209-21. doi: 10.1586/14760584.7.2.209.
Abstract
Inhalation of Yersinia pestis bacilli causes pneumonic plague, a rapidly progressing and exceptionally virulent disease. Extensively antibiotic-resistant Y. pestis strains exist and we currently lack a safe and effective pneumonic plague vaccine. These facts raise concern that Y. pestis may be exploited as a bioweapon. Here, I review the history and status of plague vaccine research and advocate that pneumonic plague vaccines should strive to prime both humoral and cellular immunity.
摘要
吸入鼠疫杆菌会引发肺鼠疫，这是一种进展迅速且极具毒性的疾病。存在广泛耐药的鼠疫杆菌菌株，而且我们目前缺乏一种安全有效的肺鼠疫疫苗。这些事实引发了人们对鼠疫杆菌可能被用作生物武器的担忧。在此，我回顾了鼠疫疫苗研究的历史和现状，并主张肺鼠疫疫苗应努力激发体液免疫和细胞免疫。
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