Medical Oncology Unit, Istituto Oncologico Veneto - IRCCS, Via Gattamelata, 64, 35128 Padova, Italy.
Anticancer Res. 2010 Jun;30(6):2311-7.
Prognostic factors such as surgery and pathology in vulvar squamous cell carcinoma are studied.
47 patients with vulva squamous cell carcinoma treated at the Gynecology Department of the University of Padua, have been retrospectively studied.
At the univariate relapse-free survival analysis, a significant association was found for histological grade, stage of disease and type of surgery. All patients presented vulvar squamous cell carcinoma: G(1) in 25 (53%), G(2) in 14 (30%), and G(3) in 8 (17%) patients. The distribution of stages was as following: stage 1 in 6 (13%), stage 2 in 20 (43%), stage 3 in 11 (23%), and stage 4 in 10 patients (21%). Radiotherapy was performed in 13 patients. Among the 47 patients evaluable: 26 (55.3%) developed local recurrence, 12 of these patients developed a second local relapse, 3 of these also had distant metastases (lung in 1 patient, lomboaortic and mediastinic lymph nodes in the other 2 patients). Stromal invasions were <or=9 mm in 14 patients with 6 relapses and >9 mm in 30 patients with 27 relapses (univariated analysis p=0 0066). Five episodes (10,6%) of thrombosis were observed.
After multivariate analysis, surgery, stage and stromal invasion over 9 mm (hazard ratio=3.1; 95% confidence interval: 1.3-7.7) proved to be the most dominant predictor for relapse-free survival. Histological grades 1 and 2 were predictive of better disease-free survival (p=0.0012).
研究了外阴鳞癌的预后因素，如手术和病理学。
回顾性研究了在帕多瓦大学妇科接受治疗的 47 例外阴鳞癌患者。
在单变量无复发生存分析中，组织学分级、疾病分期和手术类型与显著相关。所有患者均表现为外阴鳞癌：G1 期 25 例（53%），G2 期 14 例（30%），G3 期 8 例（17%）。分期分布如下：1 期 6 例（13%），2 期 20 例（43%），3 期 11 例（23%），4 期 10 例（21%）。13 例患者接受了放疗。在可评估的 47 例患者中：26 例（55.3%）出现局部复发，其中 12 例患者出现第二次局部复发，其中 3 例患者出现远处转移（1 例患者为肺，另外 2 例患者为腰主动脉和纵隔淋巴结）。间质浸润<或=9mm 的患者 14 例，有 6 例复发；间质浸润>9mm 的患者 30 例，有 27 例复发（单变量分析，p=0.0066）。观察到 5 例（10.6%）血栓形成。
多变量分析后，手术、分期和间质浸润超过 9mm（危险比=3.1；95%置信区间：1.3-7.7）被证明是无复发生存的最主要预测因素。1 级和 2 级组织学分级提示无病生存更好（p=0.0012）。
