伴有真皮淀粉样沉积的播散性浅表性汗孔角化症。

Disseminated Superficial Porokeratosis with Dermal Amyloid Deposits.

作者信息

Carlesimo M, Rossi A, Fidanza L, Narcisi A, La Pietra M, Mari E, Cacchi C, Camplone G

机构信息

U.O.C. Dermatology, II Unit University of Rome 'Sapienza', Rome, Italy.

出版信息

Case Rep Dermatol. 2009 Sep 12;1(1):35-38. doi: 10.1159/000236037.

DOI:10.1159/000236037

PMID:20652111

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2895207/

Abstract

Only 6 cases with an association of disseminated superficial porokeratosis with dermal amyloid deposits are reported in the literature. We present the case of a 76-year-old woman who presented with a disseminated superficial porokeratosis. Histological examination revealed amyloid deposits in the upper dermis, which were typed with routine HE stains, Congo red stains and anticytokeratin antibodies (AE1-AE3 and CK5). Positive staining with Congo red and, moreover, with CK5 (a cytokeratin strongly represented in the basal cell layer of the epidermis) indicates an epidermal origin of this protein.

摘要

文献中仅报道了6例播散性浅表性汗孔角化症合并真皮淀粉样沉积的病例。我们报告了一例76岁女性播散性浅表性汗孔角化症的病例。组织学检查显示真皮上层有淀粉样沉积，通过常规苏木精-伊红染色、刚果红染色和抗细胞角蛋白抗体（AE1-AE3和CK5）进行分型。刚果红染色阳性，此外，CK5（一种在表皮基底细胞层中大量表达的细胞角蛋白）染色阳性，表明该蛋白起源于表皮。