GSK3 同工型的磷酸酶 PP1 和 PP2A 调节。
Regulation of GSK3 isoforms by phosphatases PP1 and PP2A.
机构信息
Centro de Biologia Molecular Severo Ochoa (CSIC-UAM), Madrid, Spain.
出版信息
Mol Cell Biochem. 2010 Nov;344(1-2):211-5. doi: 10.1007/s11010-010-0544-0. Epub 2010 Jul 22.
PMID:20652371
Abstract
Dephosphorylation of phospho GSK3 isoforms, from COS-7 cells, was determined in vitro and in cultured cells in the absence or the presence of okadaic acid and lithium. Our results indicate a preferential dephosphorylation of phospho GSK3α by PP2A phosphatase, whereas dephosphorylation of phospho GSK3β mainly takes place by PP1 phosphatase.
摘要
从 COS-7 细胞中提取磷酸化 GSK3 同工型，在有无岗田酸和锂的情况下进行体外和培养细胞内去磷酸化实验。我们的结果表明，PP2A 磷酸酶优先使磷酸化 GSK3α 去磷酸化，而磷酸化 GSK3β 的去磷酸化主要由 PP1 磷酸酶完成。
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