Photoradiotherapy Unit, U.O. Dermatology, Fondazione IRCCS Cà Granda-Ospedale Maggiore Policlinico, Milan, Italy.
J Dermatolog Treat. 2011 Feb;22(1):38-42. doi: 10.3109/09546630903460278. Epub 2010 Jul 24.
Auricular keloids are very frequent and often have a peculiar response to therapy. Despite a variety of treatment options, recurrence is the norm. An integrated surgical-radiotherapy approach is suggested to have the most significant effect on recurrence rate, varying from 3.5% to 27%. The aim of this study was to assess, through a retrospective review of our cases, the effectiveness and safety of postoperative radiotherapy performed over 26 years and to observe whether all localizations of auricular keloids behave in the same way.
Sixty patients affected by 76 auricular keloids were included in this study. The median time interval between the surgery and the beginning of radiotherapy was 3 days. The total dose administered ranged from 10 Gy to 45 Gy, by means of weekly fractions of 5 Gy each.
The mean follow-up was 47.85 months. In 10 cases (13.2%) a recurrence occurred. The 5-year relapse-free rate from the end of the combined treatment was 79.84%. The cosmetic result was judged as good in all cases. No late stochastic or non-stochastic damages were observed.
Our data significantly support the dermatologic postoperative radiotherapy role in the treatment approach of all auricular keloids.
耳廓瘢痕疙瘩非常常见，且通常对治疗有特殊反应。尽管有多种治疗选择，但复发是常态。综合手术-放疗方法对复发率的影响最大，从 3.5%到 27%不等。本研究旨在通过回顾我们的病例，评估 26 年来术后放疗的有效性和安全性，并观察耳廓瘢痕疙瘩的所有部位是否表现相同。
本研究纳入了 60 例 76 个耳廓瘢痕疙瘩患者。手术与放疗开始之间的中位时间间隔为 3 天。总剂量为 10Gy 至 45Gy，每周 5Gy 分 5 次给予。
平均随访时间为 47.85 个月。10 例（13.2%）出现复发。联合治疗结束后 5 年无复发生存率为 79.84%。所有病例的美容效果均被评为良好。未观察到晚期随机或非随机损伤。
我们的数据显著支持皮肤科术后放疗在所有耳廓瘢痕疙瘩治疗方法中的作用。
