与败血症的恢复期相比，新生儿败血症的急性期静息能量消耗减少。
Rest energy expenditure is decreased during the acute as compared to the recovery phase of sepsis in newborns.
机构信息
Departamento de Pediatria, Universidade de São Paulo (USP), São Paulo, SP, Brasil.
出版信息
Nutr Metab (Lond). 2010 Jul 23;7:63. doi: 10.1186/1743-7075-7-63.
BACKGROUND
Little is known with respect to the metabolic response and the requirements of infected newborns. Moreover, the nutritional needs and particularly the energy metabolism of newborns with sepsis are controversial matter. In this investigation we aimed to evaluate the rest energy expenditure (REE) of newborns with bacterial sepsis during the acute and the recovery phases.
METHODS
We studied nineteen neonates (27.3 +/- 17.2 days old) with bacterial sepsis during the acute phase and recovery of their illness. REE was determined by indirect calorimetry and VO2 and VCO2 measured by gas chromatography.
RESULTS
REE significantly increased from 49.4 +/- 13.1 kcal/kg/day during the acute to 68.3 +/- 10.9 kcal/kg/day during recovery phase of sepsis (P < 0.01). Similarly, VO2 (7.4 +/- 1.9 vs 10 +/- 1.5 ml/kg/min) and VCO2 (5.1 +/- 1.7 vs 7.4 +/- 1.5 ml/kg/min) were also increased during the course of the disease (P < 0.01).
CONCLUSION
REE was increased during recovery compared to the sepsis phase. REE of septic newborns should be calculated on individualized basis, bearing in mind their metabolic capabilities.
背景
对于感染新生儿的代谢反应和需求知之甚少。此外，患有败血症的新生儿的营养需求，尤其是能量代谢，是一个有争议的问题。在这项研究中，我们旨在评估患有细菌性败血症的新生儿在急性和恢复期的静息能量消耗（REE）。
方法
我们研究了 19 名患有细菌性败血症的新生儿，他们在急性和疾病恢复期。通过间接热量法测量 REE，通过气相色谱法测量 VO2 和 VCO2。
结果
REE 从败血症的急性阶段的 49.4 +/- 13.1 kcal/kg/天显著增加到恢复阶段的 68.3 +/- 10.9 kcal/kg/天（P < 0.01）。同样，VO2（7.4 +/- 1.9 与 10 +/- 1.5 ml/kg/min）和 VCO2（5.1 +/- 1.7 与 7.4 +/- 1.5 ml/kg/min）在疾病过程中也增加（P < 0.01）。
结论
与败血症阶段相比，恢复期的 REE 增加。败血症新生儿的 REE 应根据个体情况计算，考虑到他们的代谢能力。
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