Hardy J F, Perrault J, Tremblay N, Robitaille D, Blain R, Carrier M
Department of Anaesthesia, University of Montreal, Quebec.
Can J Anaesth. 1991 May;38(4 Pt 1):511-7. doi: 10.1007/BF03007591.
The use of blood products in 1480 consecutive cases of adult cardiac surgical procedures over a period of 15 mth was studied retrospectively using the database of the Department of Anaesthesia of the Institut de Cardiologie de Montréal. Use of blood products was compared in patients having (1) coronary artery bypass grafting, (2) valvular surgery, (3) or a combination of 1 and 2. First operations were compared with reoperations. Overall, the use of homologous blood products was greatest in patients of Group 3, intermediate in patients of Group 2, and smallest in patients of Group 1. Reoperations were associated with an increase in intraoperative transfusion of packed red blood cells, but postoperative chest drainage was similar to first operations. When all blood products (packed red blood cells, fresh frozen plasma and platelets) were taken into consideration, patients undergoing primary CABG or valve surgery were the least exposed to homologous blood donors (five and six units transfused respectively). Repeat CABG was associated with an intermediate exposure to homologous blood products (eight units). Finally, primary and repeat combined procedures, and repeat valve surgery were associated with the greatest exposure to foreign blood products (10, 13 and 10 units respectively). The data presented in this study provide a rational basis for stratification of procedures according to the expected use of blood products, particularly in view of future studies which may be planned to examine the efficiency of blood conservation strategies.
利用蒙特利尔心脏病研究所麻醉科的数据库,对15个月期间连续1480例成人心脏外科手术中血制品的使用情况进行了回顾性研究。比较了接受以下手术的患者血制品的使用情况:(1)冠状动脉旁路移植术,(2)瓣膜手术,(3)或1和2的联合手术。首次手术与再次手术进行了比较。总体而言,第3组患者使用同源血制品最多,第2组患者次之,第1组患者最少。再次手术与术中浓缩红细胞输注增加有关,但术后胸腔引流量与首次手术相似。当考虑所有血制品(浓缩红细胞、新鲜冰冻血浆和血小板)时,接受初次冠状动脉旁路移植术或瓣膜手术的患者接触同源献血者的情况最少(分别输注5个和6个单位)。再次冠状动脉旁路移植术与接触同源血制品的情况居中(8个单位)。最后,初次和再次联合手术以及再次瓣膜手术接触异体血制品的情况最多(分别为10个、13个和10个单位)。本研究中呈现的数据为根据血制品的预期使用情况对手术进行分层提供了合理依据,特别是考虑到未来可能计划开展的研究,以检验血液保护策略的有效性。