Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar University, Coimbatore 641 046, Tamil Nadu, India.
Food Chem Toxicol. 2010 Oct;48(10):2848-54. doi: 10.1016/j.fct.2010.07.017. Epub 2010 Jul 21.
The impact of acute and sublethal toxicity of arsenate on hematological, biochemical and enzymological parameters of an Indian major carp Catla catla were estimated. The median lethal concentration of sodium arsenate to the fish Catla catla for 96h was found to be 43.78 mg/L. During acute treatment (43.78 mg/L), hemoglobin (Hb), hematocrit (Ht), red blood cell count (RBC), white blood cell count (WBC), plasma glucose, plasma protein, liver aspartate and alanine aminotransferase (AST and ALT) levels decreased, whereas corpuscular indices like mean cell volume (MCV), mean cell hemoglobin (MCH) and mean cell hemoglobin concentration (MCHC) increased in arsenate treated fish. In sublethal treatment (4.378 mg/L), Hb, Ht, RBC, plasma protein levels decreased while MCHC and plasma glucose levels increased throughout the exposure period. A biphasic trend was noticed in WBC, MCV, MCH, liver AST and ALT levels. The alterations of these parameters can be effectively used as a rapid method to assess health of fish exposed to arsenate in the aquatic environment.
评估了砷酸盐的急性和亚致死毒性对印度鲤鱼（Catla catla）血液学、生物化学和酶学参数的影响。发现砷酸钠对鲤鱼 Catla catla 的 96 小时半数致死浓度为 43.78mg/L。在急性处理（43.78mg/L）中，血红蛋白（Hb）、血细胞比容（Ht）、红细胞计数（RBC）、白细胞计数（WBC）、血浆葡萄糖、血浆蛋白、肝脏天冬氨酸和丙氨酸氨基转移酶（AST 和 ALT）水平降低，而红细胞指数如平均红细胞体积（MCV）、平均红细胞血红蛋白（MCH）和平均红细胞血红蛋白浓度（MCHC）在砷酸盐处理的鱼中增加。在亚致死处理（4.378mg/L）中，Hb、Ht、RBC、血浆蛋白水平降低，而整个暴露期间 MCHC 和血浆葡萄糖水平增加。WBC、MCV、MCH、肝脏 AST 和 ALT 水平呈双相趋势。这些参数的变化可以有效地用作评估鱼类在水生环境中暴露于砷酸盐的健康状况的快速方法。
