Khaleda Laila, Alam Md Mazharul, Tasnim Zarin, Ezaj Md Muzahid Ahmed, Apu Md Abdur Rahman, Akter Rasheda, Bakar Md Abu, Alam Md Jibran, Chowdhury Rahee Hasan, Datta Amit, Shawon Inzamamul Ismail, Rahman Md Zillur, Al-Forkan Mohammad
Department of Genetic Engineering and Biotechnology, Faculty of Biological Sciences, University of Chittagong, Chittagong 4331, Bangladesh.
Department of Industrial Biotechnology, Faculty of Biotechnology and Genetic Engineering, Chattogram Veterinary and Animal Sciences University, Chittagong 4225, Bangladesh.
Toxicol Rep. 2025 Mar 12;14:101993. doi: 10.1016/j.toxrep.2025.101993. eCollection 2025 Jun.
Bangladesh is heavily impacted by arsenic contamination; however, in-depth research regarding the consequences of arsenic exposure through contaminated food remains in its nascent stage.
Our study aimed to examine the effects of consuming arsenic-contaminated rice and vegetables on Wistar albino rats.
A total of 30 Wistar albino rats were divided into control and experimental groups, receiving diets containing arsenic-contaminated rice and vegetable for 120 days. Arsenic levels in food samples were quantified using FI-HG-AAS. Hematological, biochemical, and histopathological analyses were conducted to assess hepatic and renal toxicity. Statistical analysis was performed using SPSS, ANOVA, DMART with significance set at < 0.05.
In hematological studies, hemoglobin was found to be significantly reduced in exposed rats (P < 0.05) to 13.67 ± 0.54 gm/dl for rice diet and 13.77 ± 0.28 gm/dl for edible fern diet compared to control (14.17 ± 0.43 gm/dl for rice diet and 15.27 ± 0.13 gm/dl for edible fern diet), and similar results were also observed for RBC and WBC. Elevated levels of serum ALT, AST, urea and creatinine reflected hepatic and renal dysfunction. In renal and hepatic tissue histopathology, inflammation, degeneration, and fatty changes were observed. This study provides the first direct evidence of systemic toxicity from chronic dietary arsenic exposure in Bangladesh, identifying rice and vegetables as significant, underrecognized sources of arsenic-related health risks.
We conclude that eating rice and vegetables that have been exposed to arsenic over an extended period of time might be harmful to the body.
孟加拉国受到砷污染的严重影响；然而，关于通过受污染食物接触砷的后果的深入研究仍处于初期阶段。
我们的研究旨在探讨食用受砷污染的大米和蔬菜对Wistar白化大鼠的影响。
总共30只Wistar白化大鼠被分为对照组和实验组，接受含砷污染大米和蔬菜的饮食120天。使用FI-HG-AAS对食物样本中的砷含量进行定量。进行血液学、生化和组织病理学分析以评估肝脏和肾脏毒性。使用SPSS、方差分析、DMART进行统计分析，显著性设定为<0.05。
在血液学研究中，发现与对照组相比，暴露组大鼠的血红蛋白显著降低（P<0.05），大米饮食组降至13.67±0.54克/分升，可食用蕨菜饮食组降至13.77±0.28克/分升（大米饮食对照组为14.17±0.43克/分升，可食用蕨菜饮食对照组为15.27±0.13克/分升），红细胞和白细胞也观察到类似结果。血清谷丙转氨酶、谷草转氨酶、尿素和肌酐水平升高反映了肝脏和肾脏功能障碍。在肾脏和肝脏组织病理学中，观察到炎症、变性和脂肪变化。本研究提供了孟加拉国慢性饮食砷暴露导致全身毒性的首个直接证据，确定大米和蔬菜是砷相关健康风险的重要但未被充分认识的来源。
我们得出结论，长期食用受砷污染的大米和蔬菜可能对身体有害。
