Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva 84105, Israel.
J Control Release. 2010 Dec 1;148(2):204-11. doi: 10.1016/j.jconrel.2010.07.106. Epub 2010 Jul 22.
Low-frequency ultrasound application has been shown to greatly enhance transdermal drug delivery. Skin exposed to ultrasound is affected in a heterogeneous manner, thus mass transport through the stratum corneum occurs mainly through highly permeable localized transport regions (LTRs). Shock waves and microjets generated during inertial cavitations are responsible for the transdermal permeability enhancement. In this study, we evaluated the effect of these two phenomena using direct and indirect methods, and demonstrated that the contribution of microjets to skin permeability enhancement is significantly higher than shock waves.
低频超声应用已被证明可极大地增强经皮药物传递。暴露于超声下的皮肤会受到不均匀的影响，因此，通过角质层的质量传递主要通过高渗透性的局部传递区域（LTR）进行。惯性空化过程中产生的冲击波和微射流负责经皮通透性的增强。在本研究中，我们使用直接和间接方法评估了这两种现象的影响，并证明了微射流对皮肤通透性增强的贡献明显高于冲击波。
