低频超声透入疗法：综述

Low-frequency sonophoresis: a review.

作者信息

Mitragotri Samir, Kost Joseph

机构信息

Department of Chemical Engineering, University of California, Santa Barbara, CA 93106, USA.

出版信息

Adv Drug Deliv Rev. 2004 Mar 27;56(5):589-601. doi: 10.1016/j.addr.2003.10.024.

DOI:10.1016/j.addr.2003.10.024

PMID:15019748

Abstract

Application of ultrasound enhances skin permeability to a variety of molecules (sonophoresis). The enhancement induced by ultrasound is particularly significant at low-frequencies (f<100 kHz, low-frequency sonophoresis). This review summarizes mechanisms and applications of low-frequency sonophoresis. In vitro, in vivo, as well as clinical studies demonstrating the effect of low-frequency ultrasound on transdermal drug delivery and glucose extraction are summarized. Mechanistic insights gained through a number of investigations are also reviewed. Finally, reports on the synergistic effect of low-frequency ultrasound with other enhancers including chemicals and iontophoresis are summarized.

摘要

超声的应用可增强皮肤对多种分子的通透性（超声透药）。超声诱导的增强作用在低频（f<100 kHz，低频超声透药）时尤为显著。本综述总结了低频超声透药的机制和应用。总结了体外、体内以及临床研究，这些研究证明了低频超声对经皮给药和葡萄糖提取的作用。还综述了通过大量研究所获得的机制性见解。最后，总结了关于低频超声与包括化学物质和离子电渗疗法在内的其他增强剂协同作用的报告。