Department of Chemical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel.
Department of Biomedical Engineering, Ben-Gurion University, Beer-Sheva 84105, Israel.
Adv Drug Deliv Rev. 2014 Jun;72:127-43. doi: 10.1016/j.addr.2014.01.007. Epub 2014 Jan 22.
Transdermal drug delivery offers an attractive alternative to the conventional drug delivery methods of oral administration and injections. However, the stratum corneum serves as a barrier that limits the penetration of substances to the skin. Application of ultrasound (US) irradiation to the skin increases its permeability (sonophoresis) and enables the delivery of various substances into and through the skin. This review presents the main findings in the field of sonophoresis in transdermal drug delivery as well as transdermal monitoring and the mathematical models associated with this field. Particular attention is paid to the proposed enhancement mechanisms and future trends in the fields of cutaneous vaccination and gene therapy.
经皮给药为口服和注射等传统药物传递方法提供了一种有吸引力的替代方案。然而，角质层作为一种屏障，限制了物质向皮肤的渗透。将超声波（US）辐射施加于皮肤会增加其渗透性（声透法），并能够将各种物质递送至皮肤内部和穿过皮肤。本文综述了经皮药物传递领域中声透法的主要发现，以及经皮监测和与该领域相关的数学模型。特别关注了在皮肤疫苗接种和基因治疗领域中提出的增强机制和未来趋势。
