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甲醛、硫酸铜和一种商业泡脚产品控制趾间皮炎的效果。

Efficacy of formalin, copper sulfate, and a commercial footbath product in the control of digital dermatitis.

机构信息

Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.

出版信息

J Dairy Sci. 2010 Aug;93(8):3628-34. doi: 10.3168/jds.2010-3246.

Abstract

The objective was to evaluate the relative efficacy of a novel, commercially available disinfectant agent (T-Hexx Dragonhyde HBC, Hydromer, Branchburg, NJ) compared with formalin and copper sulfate. The hypothesis was 2 sided; therefore, the hypothesis was that the new agent would be better or worse compared with the industry gold standard footbath agents, formalin and copper sulfate. The study was conducted in a large commercial dairy farm located near Ithaca, New York, from June 18, 2009 to October 26, 2009. Two identical studies were conducted, the first comparing Dragonhyde (5% solution, twice weekly) and formalin (5% solution, twice weekly) and the second comparing Dragonhyde (5% solution, twice weekly) and copper sulfate (10% solution, twice weekly). The study design was identical for both studies with 4 pens (physically identical), 2 treatments (Dragonhyde vs. formalin and Dragonhyde vs. copper sulfate), 2 periods (crossing over the treatment within pen), and 3 repeated measures (3 observations per cow: enrollment, wk 2, and wk 4). For study 1, 406 cows were enrolled (n=201 formalin and 205 Dragonhyde). For study 2, 356 cows were enrolled (n=189 copper sulfate and 167 Dragonhyde). The adjusted odds of digital dermatitis lesion (DDL) throughout the study period were analyzed by mixed logistic regression model. In study 1, the odds of DDL were 1.36 times higher for the formalin group compared with the Dragonhyde group. In study 2, the data were analyzed by a similar statistical model and the variable treatment did not significantly affect the overall prevalence of DDL. In conclusion, the performance of 3 hoof care products was evaluated and it was concluded that Dragonhyde performed better than formalin and that there was no difference between copper sulfate and Dragonhyde.

摘要

目的是评估一种新型市售消毒剂(T-Hexx Dragonhyde HBC,Hydromer,Branchburg,NJ)与甲醛和硫酸铜相比的相对疗效。该假设为双侧检验,因此假设与行业金标准足浴剂甲醛和硫酸铜相比,新试剂的效果更好或更差。该研究于 2009 年 6 月 18 日至 10 月 26 日在纽约伊萨卡附近的一个大型商业奶牛场进行。进行了两项相同的研究,第一项比较了 Dragonhyde(5%溶液,每周两次)和甲醛(5%溶液,每周两次),第二项比较了 Dragonhyde(5%溶液,每周两次)和硫酸铜(10%溶液,每周两次)。两项研究的设计相同,有 4 个牛舍(在物理上完全相同)、2 种处理(Dragonhyde 与甲醛和 Dragonhyde 与硫酸铜)、2 个时期(在牛舍内交叉处理)和 3 个重复测量(每头牛 3 次观察:入组、第 2 周和第 4 周)。对于研究 1,共入组 406 头奶牛(n=201 头甲醛和 205 头 Dragonhyde)。对于研究 2,共入组 356 头奶牛(n=189 硫酸铜和 167 头 Dragonhyde)。通过混合逻辑回归模型分析整个研究期间数字皮炎病变(DDL)的调整后比值比。在研究 1 中,与 Dragonhyde 组相比,甲醛组 DDL 的可能性高 1.36 倍。在研究 2 中,使用类似的统计模型分析数据,且处理变量并未显著影响 DDL 的总体患病率。总之,评估了 3 种蹄保健产品的性能,结果表明 Dragonhyde 的效果优于甲醛,而硫酸铜和 Dragonhyde 之间没有差异。

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