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本文引用的文献

1
Reduced lymphocyte infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.白细胞介素-10 缺陷型小鼠巨细胞病毒脑感染期间淋巴细胞浸润减少。
J Neurovirol. 2009 Jul;15(4):334-42. doi: 10.1080/13550280903062797.
2
Role of IL-10 deficiency in pneumonia induced by Corynebacterium kutscheri in mice.白细胞介素-10缺乏在小鼠肺炎克雷伯氏菌诱导的肺炎中的作用。
J Microbiol Biotechnol. 2009 Apr;19(4):424-30. doi: 10.4014/jmb.0807.436.
3
Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome.小鼠脊髓损伤后Ly6G/Gr-1白细胞的耗竭会改变伤口愈合并恶化神经功能结局。
J Neurosci. 2009 Jan 21;29(3):753-64. doi: 10.1523/JNEUROSCI.4918-08.2009.
4
Prolonged microglial cell activation and lymphocyte infiltration following experimental herpes encephalitis.实验性疱疹性脑炎后小胶质细胞的长期激活和淋巴细胞浸润。
J Immunol. 2008 Nov 1;181(9):6417-26. doi: 10.4049/jimmunol.181.9.6417.
5
The immune response to herpes simplex virus type 1 infection in susceptible mice is a major cause of central nervous system pathology resulting in fatal encephalitis.在易感小鼠中，对1型单纯疱疹病毒感染的免疫反应是导致致命性脑炎的中枢神经系统病理变化的主要原因。
J Virol. 2008 Jul;82(14):7078-88. doi: 10.1128/JVI.00619-08. Epub 2008 May 14.
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Coordination of early protective immunity to viral infection by regulatory T cells.调节性T细胞对病毒感染的早期保护性免疫的协调作用。
Science. 2008 May 30;320(5880):1220-4. doi: 10.1126/science.1155209. Epub 2008 Apr 24.
7
Dysregulated interferon-gamma responses during lethal cytomegalovirus brain infection of IL-10-deficient mice.白细胞介素-10缺陷小鼠在致死性巨细胞病毒脑感染期间干扰素-γ反应失调。
Virus Res. 2007 Dec;130(1-2):96-102. doi: 10.1016/j.virusres.2007.05.022. Epub 2007 Jul 12.
8
Distinct regulation of MHC molecule expression on astrocytes and microglia during viral encephalomyelitis.病毒性脑脊髓炎期间星形胶质细胞和小胶质细胞上MHC分子表达的不同调节
Glia. 2007 Aug 15;55(11):1169-77. doi: 10.1002/glia.20538.
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Complement-dependent P-selectin expression and injury following ischemic stroke.缺血性中风后补体依赖性P-选择素的表达与损伤
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Theiler's virus induces the MIP-2 chemokine (CXCL2) in astrocytes from genetically susceptible but not from resistant mouse strains.泰勒氏病毒可在基因易感小鼠品系的星形胶质细胞中诱导MIP-2趋化因子（CXCL2）产生，而在抗性小鼠品系中则不会。
Cell Immunol. 2006 Jan;239(1):31-40. doi: 10.1016/j.cellimm.2006.03.003. Epub 2006 May 8.

白细胞介素-10缺陷小鼠巨细胞病毒脑感染期间中性粒细胞过度浸润。

Excess neutrophil infiltration during cytomegalovirus brain infection of interleukin-10-deficient mice.

作者信息

Mutnal Manohar B, Cheeran Maxim C-J, Hu Shuxian, Little Morgan R, Lokensgard James R

机构信息

Neuroimmunology Laboratory, Center for Infectious Diseases and Microbiology Translational Research, University of Minnesota Medical School, Minneapolis, MN 55455, USA.

出版信息

J Neuroimmunol. 2010 Oct 8;227(1-2):101-10. doi: 10.1016/j.jneuroim.2010.06.020. Epub 2010 Jul 24.

DOI:10.1016/j.jneuroim.2010.06.020
PMID:20655600
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2942961/
Abstract

Wild-type mice control murine cytomegalovirus (MCMV) brain infection, but identical infection is lethal to animals deficient in interleukin (IL)-10. Here, we report that MCMV-infected IL-10 knockout (KO) mice displayed a marked increase in neutrophil infiltration into the infected, IL-10-deficient brain when compared to wild-type animals. Enhanced microglial cell activation, determined by MHC class II up-regulation, overexpression of CXCL2, and elevated P-selectin mRNA levels were observed. In vivo blocking of CXCL2 attenuated neutrophil infiltration and significantly improved the outcome of infection. Collectively, these data indicate that the absence of IL-10 results in pathologic neutrophil infiltration into MCMV-infected brains.

摘要

野生型小鼠能够控制鼠巨细胞病毒（MCMV）引起的脑部感染，但相同的感染对白细胞介素（IL）-10缺陷的动物却是致命的。在此，我们报告称，与野生型动物相比，感染MCMV的IL-10基因敲除（KO）小鼠的感染脑内中性粒细胞浸润显著增加。通过MHC II类分子上调、CXCL2过表达以及P-选择素mRNA水平升高确定，小胶质细胞活化增强。体内阻断CXCL2可减轻中性粒细胞浸润，并显著改善感染结果。总体而言，这些数据表明，IL-10的缺失导致病理性中性粒细胞浸润到感染MCMV的脑内。