Endo Toshiya, Yamano Koji, Kawano Shin
Department of Chemistry, Graduate School of Science, Nagoya University, Chikusa-ku, Nagoya 464-8602, Japan.
Biochim Biophys Acta. 2011 Mar;1808(3):955-70. doi: 10.1016/j.bbamem.2010.07.018. Epub 2010 Jul 23.
Mitochondrial functions rely on precise and efficient transport of 1000-1500 different mitochondrial proteins from the cytosol to appropriate mitochondrial subcompartments. Those mitochondrial protein transport processes are mediated by the dedicated mitochondrial protein import system comprised of translocators in the outer and inner mitochondrial membranes and soluble factors in the cytosol, intermembrane space, and matrix. In the last decade, high-resolution structures of many of the components of the mitochondrial protein import machineries have become available, which has significantly advanced our understanding of the molecular mechanisms of mitochondrial protein transport. Here we review the currently available high-resolution structures of the components of the mitochondrial protein import machineries that afford structural and mechanistic insight into how the mitochondrial import system works. This article is part of a Special Issue entitled Protein translocation across or insertion into membranes.
线粒体功能依赖于1000 - 1500种不同的线粒体蛋白从细胞质精确且高效地转运至适当的线粒体亚区室。这些线粒体蛋白转运过程由专门的线粒体蛋白导入系统介导，该系统由线粒体外膜和内膜中的转运体以及细胞质、膜间隙和基质中的可溶性因子组成。在过去十年中，线粒体蛋白导入机制的许多组件的高分辨率结构已可得，这极大地推进了我们对线粒体蛋白转运分子机制的理解。在此，我们综述线粒体蛋白导入机制组件目前可得的高分辨率结构，这些结构为线粒体导入系统的工作方式提供了结构和机制上的见解。本文是名为“蛋白质跨膜转运或插入膜”的特刊的一部分。
