Department of Natural Products, National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali 160062, Punjab, India.
Fitoterapia. 2010 Dec;81(8):1129-33. doi: 10.1016/j.fitote.2010.07.013. Epub 2010 Jul 23.
The dichloromethane (MKD) and ethyl acetate (MKE) extracts of Murraya koenigii leaves significantly reduced the body weight gain, plasma total cholesterol (TC) and triglyceride (TG) levels significantly when given orally at a dose of 300 mg/kg/day to the high fat diet (HFD) induced obese rats for 2 weeks. The observed antiobesity and antihyperlipidemic activities of these extract are correlated with the carbazole alkaloids present in them. Mahanimbine (1) when given orally (30 mg/kg/day) also significantly lowered the body weight gain as well as plasma TC and TG levels. These findings demonstrate the excellent pharmacological potential of mahanimbine to prevent obesity.
九里香叶片的二氯甲烷（MKD）和乙酸乙酯（MKE）提取物在高脂饮食（HFD）诱导肥胖大鼠中，以 300mg/kg/天的剂量口服给药 2 周时，显著降低了体重增加和血浆总胆固醇（TC）和甘油三酯（TG）水平。这些提取物的观察到的抗肥胖和抗高血脂活性与它们中存在的咔唑生物碱有关。马汉宁碱（1）口服给予（30mg/kg/天）时，也显著降低了体重增加以及血浆 TC 和 TG 水平。这些发现表明马汉宁碱具有极好的预防肥胖的药理学潜力。
