Department of Food and Nutrition, Inha University, Incheon, Korea.
J Biomed Sci. 2010 Aug 24;17 Suppl 1(Suppl 1):S42. doi: 10.1186/1423-0127-17-S1-S42.
Lotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats.
Four week-old male Sprague-Dawley rats were randomly divided into four groups with 8 rats in each group for a period of 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus leaf hot water extract, HFL group; high fat diet + lotus leaf hot water extract + taurine, HFLT group). Lotus leaf hot water extract was orally administrated to HFL and HFLT groups and the same amount of distilled water was orally administered (400 mg/kg/day) to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).
The body weight gain and relative weights of epididymal and retroperitoneal adipose tissues were significantly lower in N, HFL and HFLT groups compared to HF group. HFL and HFLT groups showed lower concentrations of total cholesterol, triglyceride and low density lipoprotein cholesterol in serum. HFLT group showed higher the ratio of high density lipoprotein cholesterol/total cholesterol compared to HFL group. HFLT group showed better blood lipid profiles compared to HFL group.
Lotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats, which was more effective than lotus leaf hot water extract alone.
荷叶已被用于治疗肥胖症。本研究旨在探讨荷叶热水提取物与牛磺酸补充剂对高脂饮食诱导肥胖大鼠的减肥和降血脂作用。
4 周龄雄性 Sprague-Dawley 大鼠随机分为 4 组，每组 8 只，为期 6 周（正常饮食组，N 组；高脂饮食组，HF 组；高脂饮食+荷叶热水提取物组，HFL 组；高脂饮食+荷叶热水提取物+牛磺酸组，HFLT 组）。HFL 和 HFLT 组给予荷叶热水提取物灌胃，N 和 HF 组给予等体积蒸馏水灌胃（400mg/kg/天）。牛磺酸溶解于饲料水中添加（3%w/v）。
与 HF 组相比，N、HFL 和 HFLT 组大鼠体重增加和附睾及腹膜后脂肪组织相对重量显著降低。HFL 和 HFLT 组血清总胆固醇、甘油三酯和低密度脂蛋白胆固醇浓度较低。与 HFL 组相比，HFLT 组高密度脂蛋白胆固醇/总胆固醇比值较高。与 HFL 组相比，HFLT 组血脂谱更好。
荷叶热水提取物与牛磺酸补充剂联合使用对高脂饮食诱导肥胖大鼠具有减肥和降血脂作用，效果优于荷叶热水提取物单独使用。
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