Nambu A, Yoshida S, Jinnai K
Department of Physiology, Faculty of Medicine, Kyoto University, Japan.
Exp Brain Res. 1991;84(2):279-84. doi: 10.1007/BF00231447.
Thalamic neurons projecting to the arm area of the motor cortex were identified by their antidromic response to stimulation of that area in two awake monkeys. Neurons were further identified as receiving inputs from the cerebellar nuclei or the internal segment of the globus pallidus by excitatory or inhibitory response to stimulation of these nuclei. Most (33/34) of the thalamic neurons in the cerebello-thalamo-cortical projection and more than half (12/18) of those in the pallido-thalamo-cortical projection changed their firing rate on the lever-lifting hand movement in the reaction-time task. A considerable number of neurons of both groups (14/23 and 3/10) changed their firing rate prior to the onset of the earliest EMG. These findings agree with the model that activities of pallidal as well as cerebellar nuclear neurons related to motor control are transmitted to the motor cortex through the thalamus.
通过对两只清醒猴子运动皮层手臂区域的刺激所产生的逆向反应，确定了投射到该区域的丘脑神经元。通过对这些核团刺激产生的兴奋性或抑制性反应，进一步确定神经元接受来自小脑核团或苍白球内侧段的输入。在反应时间任务中，小脑-丘脑-皮层投射中的大多数丘脑神经元（33/34）以及苍白球-丘脑-皮层投射中的一半以上神经元（12/18）在杠杆举起手部运动时改变了它们的放电频率。两组中的相当数量神经元（14/23和3/10）在最早的肌电图开始之前就改变了它们的放电频率。这些发现与以下模型一致，即与运动控制相关的苍白球以及小脑核团神经元的活动通过丘脑传递到运动皮层。
