一种温和、简便的一锅法合成 N-甲基酰基吡咯的方法。
A mild and facile one-pot synthesis of N-methyl-acyl-pyrroles.
机构信息
Department of Chemistry, Faculty of Sciences, Azarbaijan University of Tarbiat Moallem, Tabriz, Iran.
出版信息
Molecules. 2010 Apr 27;15(5):2972-9. doi: 10.3390/molecules15052972.
Abstract
N-Methyl-3-acylpyrroles were synthesized via a multicomponent reaction of dimethylacetylene dicarboxylate (DMAD), N-methylhydroxylamine and acylchlorides in the presence of KHCO(3). For comparison both conventional and microwave protocols were examined in this procedure. The reaction is clean and gives the products in good to excellent yields under conventional heating conditions at 40 degrees C in anhydrous dichloromethane.
摘要
N-甲基-3-酰基吡咯是通过二甲基丙炔二羧酸二甲酯（DMAD）、N-甲基羟胺和酰氯在KHCO3存在下的多组分反应合成的。为了进行比较，在这个反应中同时考察了常规加热和微波两种方法。在无水二氯甲烷中，在 40°C 下进行常规加热时，反应条件温和且清洁，产物收率良好至优秀。
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