十种精油对痤疮丙酸杆菌和 PC-3、A-549 及 MCF-7 癌细胞的活性。
Activities of ten essential oils towards Propionibacterium acnes and PC-3, A-549 and MCF-7 cancer cells.
机构信息
Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040, China.
出版信息
Molecules. 2010 Apr 30;15(5):3200-10. doi: 10.3390/molecules15053200.
Ten essential oils, namely, mint (Mentha spicata L., Lamiaceae), ginger (Zingiber officinale Rosc., Zingiberaceae), lemon (Citrus limon Burm.f., Rutaceae), grapefruit (Citrus paradisi Macf., Rutaceae), jasmine (Jasminum grandiflora L., Oleaceae), lavender (Mill., Lamiaceae), chamomile (Matricaria chamomilla L., Compositae), thyme (Thymus vulgaris L., Lamiaceae), rose (Rosa damascena Mill., Rosaceae) and cinnamon (Cinnamomum zeylanicum N. Lauraceae) were tested for their antibacterial activities towards Propionibacterium acnes and in vitro toxicology against three human cancer cell lines. Thyme, cinnamon and rose essential oils exhibited the best antibacterial activities towards P. acnes, with inhibition diameters of 40 +/- 1.2 mm, 33.5 +/- 1.5 mm and 16.5 +/- 0.7 mm, and minimal inhibitory concentrations of 0.016% (v/v), 0.016% (v/v) and 0.031% (v/v), respectively. Time-kill dynamic procedures showed that thyme, cinnamon, rose, and lavender essential oils exhibited the strongest bactericidal activities at a concentration of 0.25% (v/v), and P. acnes was completely killed after 5 min. The thyme essential oil exhibited the strongest cytotoxicity towards three human cancer cells. Its inhibition concentration 50% (IC(50)) values on PC-3, A549 and MCF-7 tumor cell lines were 0.010% (v/v), 0.011% (v/v) and 0.030% (v/v), respectively. The cytotoxicity of 10 essential oils on human prostate carcinoma cell (PC-3) was significantly stronger than on human lung carcinoma (A549) and human breast cancer (MCF-7) cell lines.
十种精油，即薄荷（Mentha spicata L.，唇形科）、生姜（Zingiber officinale Rosc.，姜科）、柠檬（Citrus limon Burm.f.，芸香科）、葡萄柚（Citrus paradisi Macf.，芸香科）、茉莉（Jasminum grandiflora L.，木樨科）、薰衣草（Mill.，唇形科）、洋甘菊（Matricaria chamomilla L.，菊科）、百里香（Thymus vulgaris L.，唇形科）、玫瑰（Rosa damascena Mill.，蔷薇科）和肉桂（Cinnamomum zeylanicum N. Lauraceae），对痤疮丙酸杆菌的抗菌活性和对三种人癌细胞系的体外毒性进行了测试。百里香、肉桂和玫瑰精油对 P. acnes 的抗菌活性最好，抑菌直径分别为 40±1.2mm、33.5±1.5mm 和 16.5±0.7mm，最小抑菌浓度分别为 0.016%（v/v）、0.016%（v/v）和 0.031%（v/v）。时间杀伤动力学程序表明，百里香、肉桂、玫瑰和薰衣草精油在 0.25%（v/v）浓度下表现出最强的杀菌活性，5 分钟后 P. acnes 完全被杀灭。百里香精油对三种人癌细胞的细胞毒性最强。其对 PC-3、A549 和 MCF-7 肿瘤细胞系的 50%抑制浓度（IC50）值分别为 0.010%（v/v）、0.011%（v/v）和 0.030%（v/v）。10 种精油对人前列腺癌细胞（PC-3）的细胞毒性明显强于人肺癌（A549）和人乳腺癌（MCF-7）细胞系。
Zotero 插件