Ramsis Triveena, Refat M Selim Heba Mohammed, Elseedy Howida, Fayed Eman A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University - Kantara Branch Ismailia 41636 Egypt.
Department of Pharmaceutical Sciences, College of Pharmacy, AlMaarefa University P.O. Box 71666 Riyadh 11597 Saudi Arabia.
RSC Adv. 2024 Aug 5;14(33):24287-24321. doi: 10.1039/d4ra03865g. eCollection 2024 Jul 26.
Acne is a long-standing skin condition characterized by plugged hair follicles due to the accumulation of dead skin cells, sebum, and () bacteria, causing inflammation, and the formation of pimples or lesions. Acne was recognized in the ancient times by the ancient Egyptians, Greeks, and Romans. Since ancient times, folk medicine from different cultures have comprised herbal and natural products for the treatment of acne. Current acne medications include antibiotics, keratolytics, corticosteroids, in addition to hormonal therapy for women. However, these conventional drugs can cause some serious side effects. And therefore, seeking new safe treatment options from natural sources is essential. Plants can be a potential source of medicinal phytochemicals which can be pharmacologically active as antibacterial, antioxidant, anti-inflammatory, keratolytic and sebum-reducing. Organic acids, obtained from natural sources, are commonly used as keratolytics in dermatology and cosmetology. Most of the promising phytochemicals in acne treatment belong to terpenes, terpenoids, flavonoids, alkaloids, phenolic compounds, saponins, tannins, and essential oils. These can be extracted from leaves, bark, roots, rhizomes, seeds, and fruits of plants and may be incorporated in different dosage forms to facilitate their penetration through the skin. Additionally, medicinal compounds from marine sources can also contribute to acne treatment. This review will discuss the pathogenesis, types and consequences of acne, side effects of conventional treatment, current possible treatment options from natural sources obtained from research and folk medicine and possible applied dosage forms.
痤疮是一种长期的皮肤疾病，其特征是由于死皮细胞、皮脂和（）细菌的积聚导致毛囊堵塞，从而引发炎症，并形成丘疹或皮损。痤疮在古代就被古埃及人、希腊人和罗马人所认识。自古以来，不同文化的民间医学都包含用于治疗痤疮的草药和天然产品。目前的痤疮药物包括抗生素、角质剥脱剂、皮质类固醇，此外还有针对女性的激素疗法。然而，这些传统药物会引起一些严重的副作用。因此，从天然来源寻找新的安全治疗选择至关重要。植物可能是药用植物化学物质的潜在来源，这些物质在药理上具有抗菌、抗氧化、抗炎、角质剥脱和减少皮脂的活性。从天然来源获得的有机酸通常在皮肤病学和美容学中用作角质剥脱剂。痤疮治疗中最有前景的植物化学物质大多属于萜类、萜类化合物、黄酮类、生物碱、酚类化合物、皂苷、单宁和精油。这些物质可以从植物的叶子、树皮、根、根茎、种子和果实中提取，并可以制成不同的剂型，以促进它们透过皮肤。此外，海洋来源的药用化合物也有助于痤疮的治疗。这篇综述将讨论痤疮的发病机制、类型和后果、传统治疗的副作用、目前从研究和民间医学中获得的天然来源的可能治疗选择以及可能的应用剂型。
