• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

微波辅助无溶剂条件下一锅法合成吡唑酮衍生物。

Microwave-assisted one-pot synthesis of pyrazolone derivatives under solvent-free conditions.

机构信息

School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China.

出版信息

Molecules. 2010 May 17;15(5):3593-601. doi: 10.3390/molecules15053593.

DOI:10.3390/molecules15053593
PMID:20657501
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6263256/
Abstract

An efficient one-pot method to generate structurally diverse and medicinally interesting pyrazolone derivatives in good to excellent yields of 51-98% under microwave irradiation and solvent-free conditions has been developed.

摘要

已经开发出一种在微波辐射和无溶剂条件下高效一锅法生成结构多样且具有药用价值的吡唑啉酮衍生物的方法，产率为 51-98%。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/feb3d5e5034c/molecules-15-03593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/a6dfa8e3c65b/molecules-15-03593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/cebf7b9ed946/molecules-15-03593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/feb3d5e5034c/molecules-15-03593-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/a6dfa8e3c65b/molecules-15-03593-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/cebf7b9ed946/molecules-15-03593-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/864a/6263256/feb3d5e5034c/molecules-15-03593-g002.jpg

相似文献

1
Microwave-assisted one-pot synthesis of pyrazolone derivatives under solvent-free conditions.微波辅助无溶剂条件下一锅法合成吡唑酮衍生物。
Molecules. 2010 May 17;15(5):3593-601. doi: 10.3390/molecules15053593.
2
One-pot asymmetric synthesis of a spiro[dihydrofurocoumarin/pyrazolone] scaffold by a Michael addition/I-mediated cyclization sequence.通过迈克尔加成/I介导的环化序列一锅法不对称合成螺[二氢呋喃并香豆素/吡唑啉酮]支架。
Org Biomol Chem. 2017 Jul 21;15(27):5709-5718. doi: 10.1039/c7ob00986k. Epub 2017 Jun 26.
3
Ionic liquid under ultrasonic irradiation towards a facile synthesis of pyrazolone derivatives.超声辐射下离子液体促进的吡唑啉酮衍生物的简便合成。
Ultrason Sonochem. 2011 Jan;18(1):68-72. doi: 10.1016/j.ultsonch.2010.08.001. Epub 2010 Aug 7.
4
Asymmetric α-amination of 4-substituted pyrazolones catalyzed by a chiral Gd(OTf)3/N,N'-dioxide complex: highly enantioselective synthesis of 4-amino-5-pyrazolone derivatives.手性 Gd(OTf)3/N,N'-二氧杂环戊烷配合物催化 4-取代吡唑酮的不对称 α-胺化反应：4-氨基-5-吡唑酮衍生物的高对映选择性合成。
Org Lett. 2011 Feb 18;13(4):596-9. doi: 10.1021/ol102804p. Epub 2011 Jan 7.
5
Ultrasound-promoted greener synthesis of novel trifurcate 3-substituted-chroman-2,4-dione derivatives and their drug-likeness evaluation.超声促进新型三叉 3-取代色满-2,4-二酮衍生物的绿色合成及其类药性评价。
Molecules. 2012 Nov 28;17(12):14146-58. doi: 10.3390/molecules171214146.
6
Palladium-catalyzed double C-H activation: one-pot synthesis of benzo[c]pyrazolo[1,2-a]cinnolin-1-ones from 5-pyrazolones and aryl iodides.钯催化的双重 C-H 活化：一锅法从 5-吡唑酮和芳基碘合成苯并[c]吡唑并[1,2-a]茚满-1-酮。
Chem Commun (Camb). 2014 Feb 18;50(14):1682-4. doi: 10.1039/c3cc47989g. Epub 2014 Jan 6.
7
Microwave assisted convenient one-pot synthesis of coumarin derivatives via Pechmann condensation catalyzed by FeF3 under solvent-free conditions and antimicrobial activities of the products.在无溶剂条件下，通过FeF₃催化的Pechmann缩合反应，微波辅助便捷一锅法合成香豆素衍生物及其产物的抗菌活性。
Molecules. 2014 Aug 26;19(9):13093-103. doi: 10.3390/molecules190913093.
8
A facile four-component sequential protocol in the expedient synthesis of novel 2-aryl-5-methyl-2,3-dihydro-1H-3-pyrazolones in water and their antitubercular evaluation.一种简便的四组分连续反应序列，可在水中高效合成新型 2-芳基-5-甲基-2,3-二氢-1H-3-吡唑啉酮，并对其进行抗结核评估。
Eur J Med Chem. 2011 Sep;46(9):4530-6. doi: 10.1016/j.ejmech.2011.07.029. Epub 2011 Jul 23.
9
Copper(II)/copper(I)-catalyzed aza-Michael addition/click reaction of in situ generated alpha-azidohydrazones: synthesis of novel pyrazolone-triazole framework.铜（II）/铜（I）催化原位生成的α-叠氮腙的氮杂迈克尔加成/点击反应：新型吡唑啉酮三唑骨架的合成。
Org Lett. 2010 Feb 5;12(3):468-71. doi: 10.1021/ol902642z.
10
Development of novel pyrazolone derivatives as inhibitors of aldose reductase: an eco-friendly one-pot synthesis, experimental screening and in silico analysis.新型吡唑啉酮衍生物的开发作为醛糖还原酶抑制剂：一种环保的一锅合成、实验筛选和计算机分析。
Bioorg Chem. 2014 Apr;53:67-74. doi: 10.1016/j.bioorg.2014.02.002. Epub 2014 Feb 19.

引用本文的文献

1
1,3-diarylpyrazolones as potential anticancer agents for non-small cell lung cancer: Synthesis and antiproliferative activity evaluation.1,3-二芳基吡唑酮类化合物作为潜在的非小细胞肺癌抗癌药物：合成及抗增殖活性评价。
Chem Biol Drug Des. 2022 Apr;99(4):620-633. doi: 10.1111/cbdd.14030. Epub 2022 Mar 1.
2
Microwave-assisted synthesis of biologically relevant steroidal 17--pyrazol-5'-ones from a norpregnene precursor by a side-chain elongation/heterocyclization sequence.通过侧链延长/杂环化序列，以降孕烯前体为原料微波辅助合成具有生物学相关性的甾体17-吡唑-5'-酮。
Beilstein J Org Chem. 2018 Oct 8;14:2589-2596. doi: 10.3762/bjoc.14.236. eCollection 2018.
3

本文引用的文献

1
Recent applications of microwave irradiation to medicinal chemistry.微波辐射在药物化学中的最新应用。
Future Med Chem. 2010 Feb;2(2):169-76. doi: 10.4155/fmc.09.144.
2
Microwave-assisted cycloaddition reactions.微波辅助环加成反应。
Chem Soc Rev. 2010 May;39(5):1467-77. doi: 10.1039/b815717k. Epub 2009 Dec 1.
3
Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: part 2. Synthesis of rigid pyrazolones.新型吡唑类似物作为结核分枝杆菌抑制剂的合成、生物学评价及构效关系研究：第2部分。刚性吡唑啉酮的合成。
Streocontrolled construction of six vicinal stereogenic centers on spiropyrazolones via organocascade Michael/Michael/1,2-addition reactions.
通过有机级联迈克尔/迈克尔/1,2-加成反应在螺吡唑酮上构建六个相邻的立体手性中心的立体控制。
Org Lett. 2014 Jun 6;16(11):2954-7. doi: 10.1021/ol501093v. Epub 2014 May 19.
Bioorg Med Chem. 2009 Aug 1;17(15):5716-21. doi: 10.1016/j.bmc.2009.05.058. Epub 2009 May 29.
4
Pharmacophore and docking-based combined in-silico study of KDR inhibitors.基于药效团和对接的KDR抑制剂计算机辅助联合研究
J Mol Graph Model. 2009 Aug;28(1):54-61. doi: 10.1016/j.jmgm.2009.04.006. Epub 2009 Apr 19.
5
Pyrazolidine-3,5-dione derivatives as potent non-steroidal agonists of farnesoid X receptor: virtual screening, synthesis, and biological evaluation.吡唑烷-3,5-二酮衍生物作为法尼醇X受体的强效非甾体激动剂：虚拟筛选、合成及生物学评价
Bioorg Med Chem Lett. 2008 Oct 15;18(20):5497-502. doi: 10.1016/j.bmcl.2008.09.027. Epub 2008 Sep 10.
6
Discovery of new Gram-negative antivirulence drugs: structure and properties of novel E. coli WaaC inhibitors.新型革兰氏阴性抗毒力药物的发现：新型大肠杆菌WaaC抑制剂的结构与性质
Bioorg Med Chem Lett. 2008 Jul 15;18(14):4022-6. doi: 10.1016/j.bmcl.2008.05.117. Epub 2008 Jun 5.
7
Synthesis and molluscicidal activity of new chromene and pyrano[2,3-c]pyrazole derivatives.新型色烯和吡喃并[2,3-c]吡唑衍生物的合成及其杀螺活性
Arch Pharm (Weinheim). 2007 Oct;340(10):543-8. doi: 10.1002/ardp.200700157.
8
Controlled microwave heating in modern organic synthesis.现代有机合成中的可控微波加热。
Angew Chem Int Ed Engl. 2004 Nov 26;43(46):6250-84. doi: 10.1002/anie.200400655.
9
One-pot two-step microwave-assisted reaction in constructing 4,5-disubstituted pyrazolopyrimidines.
Org Lett. 2003 Oct 2;5(20):3587-90. doi: 10.1021/ol035226w.
10
Pyrazolone derivatives.吡唑啉酮衍生物
Drugs. 1986;32 Suppl 4:60-70. doi: 10.2165/00003495-198600324-00006.